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Estimating the Glomerular Filtration Rate in Pediatric Patients With Neurogenic Bladder: A Comparison Between Creatinine- and Cystatin C-Equations

2023-07Journal article Open access
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dc.contributor.authorMenezes, Catarina
dc.contributor.authorCosta, Teresa
dc.contributor.authorBrás, Catarina
dc.contributor.authorSousa, Patrícia
dc.contributor.authorMendes, Ana
dc.contributor.authorAmorim, Rosa
dc.contributor.authorFaria, Maria Do Sameiro
dc.contributor.authorMota, Conceição
dc.date.accessioned2024-06-18T11:21:21Z
dc.date.available2024-06-18T11:21:21Z
dc.date.issued2023-07
dc.description.abstractBackground and objective Patients with neurogenic bladder (NB) are at a higher risk of developing chronic kidney disease (CKD). Due to their lower muscle mass, the estimated glomerular filtration rate (eGFR) based on creatinine (Cr) may be overestimated and delay the diagnosis of renal failure. This study compared eGFR calculated with different equations based on Cr and/or cystatin C (CysC) in children with NB, and the differences between patients with lower muscle mass (underdeveloped lower limbs) and those with independent gait (less muscle depletion). Methods We calculated the eGFR in pediatric patients with NB and CKD stages 1 and 2 by using the following equations: Chronic Kidney Disease in Children equation for serum creatinine (CKiD-Cr), CKiD-CysC, CKiD combined-Cr/CysC, Zappitelli-CysC, and Zappitelli combined-Cr/CysC. Results We evaluated a total of 47 patients, 74.5% with CKD stage 1, with a median age of 14.1 years. Of these participants, 59.6% had lipo/myelomeningocele. The CKiD-Cr and CysC-based equations led to significantly lower calculated eGFR ​​(p<0.05), specifically CKiD-CysC (p<0.001), Zappitelli-CysC (p<0.001), CKiD-Cr/CysC (p<0.001), and Zappitelli combined-Cr/CysC (p<0.05). When CKiD-CysC was used, 68% of the patients moved to a more advanced CKD stage. In patients without independent gait, with lower muscle mass (55.3%), the median eGFR calculated using the CKiD-Cr and CKiD combined-Cr/CysC equations was significantly higher (p<0.05). However, there were no differences between the two groups when using the other CysC-based equations. Conclusion In patients with NB and poor muscle mass, the CKiD-Cr equation may overestimate renal function. CysC-based equations seem more reliable in these patients, especially in those with greater muscular atrophy.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMenezes C, Costa T, Brás C, et al. Estimating the Glomerular Filtration Rate in Pediatric Patients With Neurogenic Bladder: A Comparison Between Creatinine- and Cystatin C-Equations. Cureus. 2023;15(7):e42337. doi:10.7759/cureus.42337pt_PT
dc.identifier.doi10.7759/cureus.42337pt_PT
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.16/2960
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCureus, Inc.pt_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/166010-estimating-the-glomerular-filtration-rate-in-pediatric-patients-with-neurogenic-bladder-a-comparison-between-creatinine--and-cystatin-c-equations#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectchildren'spt_PT
dc.subjectegfr creatininept_PT
dc.subjectegfr cystatin cpt_PT
dc.subjectestimating equationspt_PT
dc.subjectglomerular filtration rate (gfr)pt_PT
dc.subjectneurogenic bladderpt_PT
dc.titleEstimating the Glomerular Filtration Rate in Pediatric Patients With Neurogenic Bladder: A Comparison Between Creatinine- and Cystatin C-Equationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPagee42337pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume15pt_PT
person.familyNameMenezes
person.familyNameFaria
person.givenNameCatarina
person.givenNameMaria do Sameiro
person.identifier.ciencia-idCD12-BF24-65FE
person.identifier.orcid0000-0001-7678-6693
person.identifier.orcid0000-0002-8061-9289
person.identifier.scopus-author-id6507433703
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication551ace4b-1735-4323-b715-edc99c0bd61b
relation.isAuthorOfPublicationad1e4a67-acf1-4b16-9ad8-659ad9fa5bd3
relation.isAuthorOfPublication.latestForDiscovery551ace4b-1735-4323-b715-edc99c0bd61b

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