Publication
Methadone Withdrawal-Related Psychosis in a Patient With Hormone-Dependent Breast Cancer: A Case Report
| dc.contributor.author | Pinho, Mauro | |
| dc.contributor.author | Martins, Daniela O | |
| dc.contributor.author | Coutinho, Francisco | |
| dc.date.accessioned | 2024-06-18T12:36:14Z | |
| dc.date.available | 2024-06-18T12:36:14Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | Methadone withdrawal usually presents as a classical opiate withdrawal syndrome, including symptoms such as restlessness, pupillary dilation, sweating, insomnia, irritability, sneezing, nausea, vomiting, and diarrhea. It rarely manifests as psychosis. Here, we discuss the case of a 43-year-old female with a history of long-term methadone use who presented with first-episode psychosis during methadone down-titration. She exhibited persecutory delusions and auditory hallucinations, unrelated to classical opiate withdrawal symptoms. Medical tests were unremarkable. The patient was diagnosed with first-episode psychosis and was involuntarily admitted to our psychiatric hospital. As she suffered from hormone-dependent breast cancer and presented paliperidone-induced hyperprolactinemia, we switched this drug to aripiprazole, a prolactin-sparing antipsychotic. Her psychotic symptoms remitted in six weeks, with no reintroduction of methadone. It remains unclear whether this presentation is attributable to a rare manifestation of withdrawal or methadone's antipsychotic properties, masking an underlying psychotic disorder. This case contributes to understanding psychosis emergence post-opioid withdrawal, underscoring the need for further investigation into withdrawal-related psychosis and opioid antipsychotic properties. It also prompts the discussion of antipsychotic treatment in patients with comorbid breast cancer, while evidence about hyperprolactinemia as a risk factor for breast cancer remains conflicting | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Pinho M, Martins DO, Coutinho F. Methadone Withdrawal-Related Psychosis in a Patient With Hormone-Dependent Breast Cancer: A Case Report. Cureus. 2023;15(12):e51240. doi:10.7759/cureus.51240 | pt_PT |
| dc.identifier.doi | 10.7759/cureus.51240 | pt_PT |
| dc.identifier.issn | 2168-8184 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/2970 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Cureus, Inc. | pt_PT |
| dc.relation.publisherversion | https://www.cureus.com/articles/217142-methadone-withdrawal-related-psychosis-in-a-patient-with-hormone-dependent-breast-cancer-a-case-report#!/ | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | addiction | pt_PT |
| dc.subject | aripiprazole | pt_PT |
| dc.subject | breast cancer | pt_PT |
| dc.subject | methadone withdrawal | pt_PT |
| dc.subject | opioid | pt_PT |
| dc.subject | prolactin | pt_PT |
| dc.subject | psychosis | pt_PT |
| dc.title | Methadone Withdrawal-Related Psychosis in a Patient With Hormone-Dependent Breast Cancer: A Case Report | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | United States of America | pt_PT |
| oaire.citation.issue | 12 | pt_PT |
| oaire.citation.startPage | e51240 | pt_PT |
| oaire.citation.title | Cureus | pt_PT |
| oaire.citation.volume | 15 | pt_PT |
| person.familyName | Pinho | |
| person.givenName | Mauro | |
| person.identifier.orcid | 0009-0004-1947-3008 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 6dc0e753-b070-4650-b709-5f4edaa80c4a | |
| relation.isAuthorOfPublication.latestForDiscovery | 6dc0e753-b070-4650-b709-5f4edaa80c4a |