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Choroidal Blood Flow After Intravitreal Ranibizumab in Vitrectomized and Non-Vitrectomized Eyes with Diabetic Macular Edema

2021-10Journal article Open access
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dc.contributor.authorPessoa, Bernardete
dc.contributor.authorMarques, Joao Heitor
dc.contributor.authorLeite, João
dc.contributor.authorSilva, Nisa
dc.contributor.authorJosé, Diana
dc.contributor.authorCoelho, Constança
dc.contributor.authorFigueira, João P
dc.contributor.authorMeireles, Angelina
dc.contributor.authorBeirão, João
dc.date.accessioned2023-10-23T08:39:39Z
dc.date.available2023-10-23T08:39:39Z
dc.date.issued2021-10
dc.description.abstractAim: Diabetic retinopathy staging system and progression predictors are soon to be considered insufficient for ophthalmologic practice. Given the growing evidence of the role of choroidal dysfunction, our purpose was to assess choroidal vascular changes with intravitreal ranibizumab (RBZ) treatment in diabetic macular edema (DME). Methods: This was a prospective longitudinal cohort study. The study included DME eyes, grouped in vitrectomized (group 1) and non-vitrectomized (group 2) eyes, submitted to RBZ in a pro re nata regimen, with 24 weeks of follow-up. Main outcome measures such as central subfield foveal thickness (CFT), choroidal thickness (CT), and choroidal vascular index (CVI) were obtained from structural OCT, and choriocapillaris flow density (CCD) was obtained from OCT angiography and analyzed before and after treatment. Results: Thirty-one patients were included, 10 eyes in group 1 and 24 eyes in group 2. The mean number of injections was 5.18 (range 2-6). Globally, there was an improvement in BCVA (+4.3 ETDRS letters, p=0.004) and CFT (-84.6 µm, p<0.001) with no changes in CT, CVI, or CCD (p>0.05). When considering only group 2, there was a significant decrease in CT (p=0.033) and a significant increase in CCD (p=0.010) 6 months after treatment, with no differences in CVI (p=0.111). Baseline CVI was correlated with visual acuity at week 24 both globally (r=0.406, p=0.029) and in group 2 (r=0.604, p=0.004). Conclusion: In non-vitrectomized eyes, choriocapillaris blood flow improves with RBZ. Baseline CVI may correlate with visual function after RBZ. ClinicalTrials.gov NCT04387604.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPessoa B, Marques JH, Leite J, et al. Choroidal Blood Flow After Intravitreal Ranibizumab in Vitrectomized and Non-Vitrectomized Eyes with Diabetic Macular Edema. Clin Ophthalmol. 2021;15:4081-4090. doi:10.2147/OPTH.S325037pt_PT
dc.identifier.doi10.2147/OPTH.S325037pt_PT
dc.identifier.issn1177-5467
dc.identifier.issn1177-5483
dc.identifier.urihttp://hdl.handle.net/10400.16/2830
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherDove Medical Presspt_PT
dc.relation.publisherversionhttps://www.dovepress.com/choroidal-blood-flow-after-intravitreal-ranibizumab-in-vitrectomized-a-peer-reviewed-fulltext-article-OPTHpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectchoriocapillaris flowpt_PT
dc.subjectchoroidal vascular indexpt_PT
dc.subjectdiabetic macular edemapt_PT
dc.subjectranibizumabpt_PT
dc.subjectvitrectomypt_PT
dc.titleChoroidal Blood Flow After Intravitreal Ranibizumab in Vitrectomized and Non-Vitrectomized Eyes with Diabetic Macular Edemapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceNew Zealandpt_PT
oaire.citation.endPage4090pt_PT
oaire.citation.startPage4081pt_PT
oaire.citation.titleClinical Ophthalmologypt_PT
oaire.citation.volumeVolume 15pt_PT
person.familyNamePessoa
person.familyNameMarques
person.familyNameSilva
person.familyNameJosé
person.familyNameCoelho
person.familyNameFigueira
person.familyNameMeireles
person.familyNameBeirão
person.givenNameBernardete
person.givenNameJoao Heitor
person.givenNameNisa
person.givenNameDiana
person.givenNameConstança
person.givenNameJoão P
person.givenNameAngelina
person.givenNameJoão Nuno Melo
person.identifier.ciencia-id0E1B-7EB2-B90F
person.identifier.ciencia-id7515-8385-064B
person.identifier.ciencia-idEF12-4F5F-7831
person.identifier.ciencia-id0214-5233-EE9D
person.identifier.orcid0000-0002-5673-1561
person.identifier.orcid0000-0001-6487-7950
person.identifier.orcid0000-0002-5607-3212
person.identifier.orcid0000-0002-8415-0780
person.identifier.orcid0000-0002-5331-2257
person.identifier.orcid0000-0002-3511-1515
person.identifier.orcid0000-0001-9148-2786
person.identifier.orcid0000-0001-8642-7010
person.identifier.scopus-author-id7005608345
person.identifier.scopus-author-id36647626200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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