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Acute tubulointersticial nephritis with uveitis: A report of two cases

2018Journal article Open access
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dc.contributor.authorSilva, F.
dc.contributor.authorCorreia, S.
dc.contributor.authorCastro, A.
dc.contributor.authorMoreira, C.
dc.contributor.authorSantos, S.
dc.contributor.authorMalheiro, J.
dc.contributor.authorSantos, J.
dc.contributor.authorMartins, L.
dc.contributor.authorCabrita, A.
dc.date.accessioned2018-11-06T10:51:23Z
dc.date.available2018-11-06T10:51:23Z
dc.date.issued2018
dc.description.abstractTubulointersticial nephritis and uveitis syndrome is an idiopathic and rare cause of acute kidney injury that should not overlooked, because it usually requires specific therapeutic interventions. We report two distinct cases: a young and an elder female. Both cases presented with unspecific constitutional symptoms but had different onset of renal and ocular involvement. Both were treated with topical and systemic corticoids and although there was a good initial response in both cases, an early relapse after steroids taper was observed in the younger patient and a persistent renal dysfunction in the older one. A high clinical suspicion and understanding of this disease is necessary for an adequate management and treatment of these patients. Recent data associates a worse renal prognosis when the disease appears in advanced age. In both of our cases the outcome was good but we had a short follow-up. The histological presentation of this disease in our older patient was similar to that reported in the literature, with a high percentage of fibrosis and chronicity of renal tissue that can contribute to the higher grade of renal dysfunction in this type of patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPort J Nephrol Hypert 2018; 32(2): 191-195pt_PT
dc.identifier.issn2183-1289
dc.identifier.urihttp://hdl.handle.net/10400.16/2251
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Portuguesa de Nefrologiapt_PT
dc.relation.publisherversionhttp://www.spnefro.pt/rpnh/browse_all_issues/68_volume_32_number_2pt_PT
dc.subjecttubulointerstitial nephritispt_PT
dc.subjectanterior uveitispt_PT
dc.subjectglucocorticoidspt_PT
dc.subjectrenal dysfunctionpt_PT
dc.titleAcute tubulointersticial nephritis with uveitis: A report of two casespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlacePortugalpt_PT
oaire.citation.endPage195pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage191pt_PT
oaire.citation.titlePortuguese Journal of Nephrology and Hypertensionpt_PT
oaire.citation.volume32pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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