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Disseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated with Metabolic Syndrome

dc.contributor.authorSantos, Ana P
dc.contributor.authorCastro, C.
dc.contributor.authorAntunes, Luís
dc.contributor.authorHenrique, Rui
dc.contributor.authorCardoso, Helena
dc.contributor.authorMP, Monteiro
dc.date.accessioned2020-05-22T15:59:06Z
dc.date.available2020-05-22T15:59:06Z
dc.date.issued2019-09-17
dc.description.abstractThe association of well-differentiated gastro-entero-pancreatic neuroendocrine tumors (WD GEP-NETs) with metabolic syndrome (MetS), abdominal obesity, and fasting glucose abnormalities was recently described. The aim of this study was to evaluate whether the presence of MetS or any MetS individual component was also influenced by GEP-NET characteristics at diagnosis. A cohort of patients with WD GEP-NETs (n = 134), classified according to primary tumor location (gastrointestinal or pancreatic), pathological grading (G1 (Ki67 ≤ 2%) and G2 (>3 ≤ 20%) (WHO 2010), disease extension (localized, loco-regional, and metastatic), and presence of hormonal secretion syndrome (functioning/non-functioning), was evaluated for the presence of MetS criteria. After adjustment for age and gender, the odds of having MetS was significantly higher for patients with WD GEP-NET grade G1 (OR 4.35 95%CI 1.30-14.53) and disseminated disease (OR 4.52 95%CI 1.44-14.15). GEP-NET primary tumor location or secretory syndrome did not influence the risk for MetS. None of the tumor characteristics evaluated were associated with body mass index, fasting plasma glucose category, or any of the individual MetS components. Patients with GEP-NET and MetS depicted a higher risk of presenting a lower tumor grade and disseminated disease. The positive association between MetS and GEP-NET characteristics further highlights the potential link between the two conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos AP, Castro C, Antunes L, Henrique R, Cardoso MH, Monteiro MP. Disseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated with Metabolic Syndrome. J Clin Med. 2019;8(9):1479. Published 2019 Sep 17. doi:10.3390/jcm8091479pt_PT
dc.identifier.doi10.3390/jcm8091479pt_PT
dc.identifier.issn077-0383
dc.identifier.urihttp://hdl.handle.net/10400.16/2397
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/8/9/1479pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectfasting glucose abnormalitiespt_PT
dc.subjectgastro-entero-pancreatic neuroendocrine tumorpt_PT
dc.subjectmetabolic syndromept_PT
dc.subjectvisceral obesitypt_PT
dc.titleDisseminated Well-Differentiated Gastro-Entero-Pancreatic Tumors Are Associated with Metabolic Syndromept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1479pt_PT
oaire.citation.titleJournal of clinical medicinept_PT
oaire.citation.volume8pt_PT
person.familyNameSantos
person.familyNameLopes Botelho Antunes
person.familyNameFerreira Henrique
person.familyNameCardoso
person.familyNameMonteiro
person.givenNameAna
person.givenNameLuís Jorge
person.givenNameRui Manuel
person.givenNameMaria Helena
person.givenNameMariana
person.identifierI-2757-2013
person.identifierR-000-958
person.identifier.ciencia-id191A-2C57-EDA4
person.identifier.ciencia-id641F-FE09-15E6
person.identifier.ciencia-id0212-CE45-8889
person.identifier.ciencia-id4014-C7BC-ED88
person.identifier.orcid0000-0002-8896-305X
person.identifier.orcid0000-0002-3098-0711
person.identifier.orcid0000-0003-3171-4666
person.identifier.orcid0000-0002-9465-5918
person.identifier.orcid0000-0002-0662-1831
person.identifier.ridP-6822-2017
person.identifier.scopus-author-id6701654252
person.identifier.scopus-author-id56817857700
person.identifier.scopus-author-id12243571300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverya1dc4387-f35c-447a-be66-d81fc5fde281

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