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Wearable artificial kidney and wearable ultrafiltration device vascular access-future directions

2019-04Journal article Open access
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dc.contributor.authorCastro, Ana
dc.contributor.authorNeri, M.
dc.contributor.authorNayak Karopadi, A.
dc.contributor.authorLorenzin, A.
dc.contributor.authorMarchionna, N.
dc.contributor.authorRonco, C.
dc.date.accessioned2020-05-06T22:27:52Z
dc.date.available2020-05-06T22:27:52Z
dc.date.issued2019-04
dc.description.abstractBackground: Since 2005, three human clinical trials have been performed with the Wearable Artificial Kidney (WAK) and Wearable Ultrafiltration (WUF) device. The lack of an adequate vascular access (VA) has been pointed out as the main limitation to their implementation. Based on the current level of understanding, we will make the first conceptual proposal of an adequate VA suitable for the WAK and the WUF. Methods: All the literature related to WAK and WUF was reviewed. Based on eight main publications the VA major characteristics were defined: a mean blood flow of 100 mL/min; the capability to allow prolonged and frequent dialysis treatments, without interfering in activities of daily living (ADL); safe and convenient connection/disconnection systems; reduced risk of biofilm formation and coagulation; high biocompatibility. A research was done in order to answer to each necessary technological prerequisites. Results: The use of a device similar to a CVC with a 5Fr lumen, seems to be the most feasible option. Totally subcutaneous port devices, like the LifeSite(R) or Dialock (R) systems can be a solution to allow WAK or WUF to operate continuously while patients carry out their ADL. Recently, macromolecules that reduce the risk of thrombosis and infection and are integrated into a CVC have been developed and have the capability of overcoming these major limitations. Conclusion: With an adequate VA, portable HD devices can be acceptable options to address several unmet clinical needs of HD patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCastro AC, Neri M, Nayak Karopadi A, Lorenzin A, Marchionna N, Ronco C. Wearable artificial kidney and wearable ultrafiltration device vascular access-future directions. Clin Kidney J. 2019;12(2):300‐307. doi:10.1093/ckj/sfy086pt_PT
dc.identifier.doi10.1093/ckj/sfy086pt_PT
dc.identifier.issn2048-8505
dc.identifier.issn2048-8513
dc.identifier.urihttp://hdl.handle.net/10400.16/2368
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relation.publisherversionhttps://academic.oup.com/ckj/article/12/2/300/5103441pt_PT
dc.subjectend-stage renal diseasept_PT
dc.subjectrenal replacement therapypt_PT
dc.subjectvascular accesspt_PT
dc.subjectwearable artificial kidneypt_PT
dc.subjectwearable ultrafiltration devicept_PT
dc.titleWearable artificial kidney and wearable ultrafiltration device vascular access-future directionspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.endPage307pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage300pt_PT
oaire.citation.titleClinical kidney journalpt_PT
oaire.citation.volume12pt_PT
person.familyNameCastro
person.givenNameAna
person.identifier.ciencia-idC012-7D92-E4A3
person.identifier.orcid0000-0001-8328-2805
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication84cd7cbf-1683-4893-a73a-da16a8a4cdd3
relation.isAuthorOfPublication.latestForDiscovery84cd7cbf-1683-4893-a73a-da16a8a4cdd3

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