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HIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysis

2013Journal article Open access
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dc.contributor.authorCarreira, H.
dc.contributor.authorCoutinho, F.
dc.contributor.authorCarrilho, C.
dc.contributor.authorLunet, N.
dc.date.accessioned2014-10-22T23:24:28Z
dc.date.available2014-10-22T23:24:28Z
dc.date.issued2013
dc.description.abstractBACKGROUND: The frequency of ocular surface squamous neoplasias (OSSNs) has been increasing in populations with a high prevalence of infection with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and infection with human papillomavirus (HPV). We aimed to quantify the association between HIV/AIDS and HPV infection and OSSN, through systematic review and meta-analysis. METHODS: The articles providing data on the association between HIV/AIDS and/or HPV infection and OSSN were identified in MEDLINE, SCOPUS and EMBASE searched up to May 2013, and through backward citation tracking. The DerSimonian and Laird method was used to compute summary relative risk (RR) estimates and 95% confidence intervals (95% CI). Heterogeneity was quantified with the I(2) statistic. RESULTS: HIV/AIDS was strongly associated with an increased risk of OSSN (summary RR=8.06, 95% CI: 5.29-12.30, I(2)=56.0%, 12 studies). The summary RR estimate for the infection with mucosal HPV subtypes was 3.13 (95% CI: 1.72-5.71, I(2)=45.6%, 16 studies). Four studies addressed the association between both cutaneous and mucosal HPV subtypes and OSSN; the summary RR estimates were 3.52 (95% CI: 1.23-10.08, I(2)=21.8%) and 1.08 (95% CI: 0.57-2.05, I(2)=0.0%), respectively. CONCLUSION: Human immunodeficiency virus infection increases the risk of OSSN by nearly eight-fold. Regarding HPV infection, only the cutaneous subtypes seem to be a risk factor.por
dc.identifier.citationBr J Cancer. 2013 Oct 1;109(7):1981-8. doi: 10.1038/bjc.2013.539.por
dc.identifier.doi10.1038/bjc.2013.539
dc.identifier.issn0007-0920
dc.identifier.urihttp://hdl.handle.net/10400.16/1709
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherLewispor
dc.relation.publisherversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790185/por
dc.titleHIV and HPV infections and ocular surface squamous neoplasia: systematic review and meta-analysispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpor
oaire.citation.endPage1988por
oaire.citation.startPage1981por
oaire.citation.titleBritish journal of cancerpor
oaire.citation.volume109(7)por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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