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Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study

2023-08Journal article Open access
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dc.contributor.authorSantos-Antunes, João
dc.contributor.authorPioche, Mathieu
dc.contributor.authorRamos-Zabala, Felipe
dc.contributor.authorCecinato, Paolo
dc.contributor.authorGallego, Francisco
dc.contributor.authorBarreiro, Pedro
dc.contributor.authorMascarenhas, André
dc.contributor.authorSferrazza, Sandro
dc.contributor.authorBerr, Frieder
dc.contributor.authorWagner, Andrej
dc.contributor.authorLemmers, Arnaud
dc.contributor.authorFerreira, Mariana Figueiredo
dc.contributor.authorAlbéniz, Eduardo
dc.contributor.authorUchima, Hugo
dc.contributor.authorKüttner-Magalhães, Ricardo
dc.contributor.authorFernandes, Carlos
dc.contributor.authorMorais, Rui
dc.contributor.authorGupta, Sunil
dc.contributor.authorMartinho-Dias, Daniel
dc.contributor.authorFaria-Ramos, Isabel
dc.contributor.authorMarques, Margarida
dc.contributor.authorBourke, Michael J.
dc.contributor.authorMacedo, Guilherme
dc.date.accessioned2024-07-04T11:33:10Z
dc.date.available2024-07-04T11:33:10Z
dc.date.issued2023-08
dc.description.abstractEndoscopic submucosal dissection (ESD) in colorectal lesions is demanding, and a significant rate of non-curative procedures is expected. We aimed to assess the rate of residual lesion after a piecemeal ESD resection, or after an en bloc resection but with positive horizontal margins (local-risk resection-LocRR), for colorectal benign neoplasia. A retrospective multicenter analysis of consecutive colorectal ESDs was performed. Patients with LocRR ESDs for the treatment of benign colorectal lesions with at least one follow-up endoscopy were included. A cohort of en bloc resected lesions, with negative margins, was used as the control. A total of 2255 colorectal ESDs were reviewed; 352 of the ESDs were "non-curative". Among them, 209 were LocRR: 133 high-grade dysplasia and 76 low-grade dysplasia. Ten cases were excluded due to missing data. A total of 146 consecutive curative resections were retrieved for comparison. Compared to the "curative group", LocRRs were observed in lengthier procedures, with larger lesions, and in non-granular LSTs. Recurrence was higher in the LocRR group (16/199, 8% vs. 1/146, 0.7%; p = 0.002). However, statistical significance was lost when considering only en bloc resections with positive horizontal margins (p = 0.068). In conclusion, a higher rate of residual lesion was found after a piecemeal ESD resection, but not after an en bloc resection with positive horizontal margins.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantos-Antunes J, Pioche M, Ramos-Zabala F, et al. Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study. J Clin Med. 2023;12(16):5356. doi:10.3390/jcm12165356pt_PT
dc.identifier.doi10.3390/jcm12165356pt_PT
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.16/2998
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/jcm12165356pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcolorectal lesionspt_PT
dc.subjectendoscopic submucosal dissectionpt_PT
dc.subjectlateral spreading tumorpt_PT
dc.subjectlocal-risk resectionpt_PT
dc.subjectpiecemeal resectionpt_PT
dc.subjectresidual lesionpt_PT
dc.titleRisk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage5356pt_PT
oaire.citation.titleJournal of Clinical Medicinept_PT
oaire.citation.volume12pt_PT
person.familyNameKüttner-Magalhães
person.givenNameRicardo
person.identifier.ciencia-idF31A-B091-3D92
person.identifier.orcid0000-0002-8522-5756
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication31c5be90-3d09-4853-8197-c5e03608e482
relation.isAuthorOfPublication.latestForDiscovery31c5be90-3d09-4853-8197-c5e03608e482

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