Publication
Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study
dc.contributor.author | Santos-Antunes, João | |
dc.contributor.author | Pioche, Mathieu | |
dc.contributor.author | Ramos-Zabala, Felipe | |
dc.contributor.author | Cecinato, Paolo | |
dc.contributor.author | Gallego, Francisco | |
dc.contributor.author | Barreiro, Pedro | |
dc.contributor.author | Mascarenhas, André | |
dc.contributor.author | Sferrazza, Sandro | |
dc.contributor.author | Berr, Frieder | |
dc.contributor.author | Wagner, Andrej | |
dc.contributor.author | Lemmers, Arnaud | |
dc.contributor.author | Ferreira, Mariana Figueiredo | |
dc.contributor.author | Albéniz, Eduardo | |
dc.contributor.author | Uchima, Hugo | |
dc.contributor.author | Küttner-Magalhães, Ricardo | |
dc.contributor.author | Fernandes, Carlos | |
dc.contributor.author | Morais, Rui | |
dc.contributor.author | Gupta, Sunil | |
dc.contributor.author | Martinho-Dias, Daniel | |
dc.contributor.author | Faria-Ramos, Isabel | |
dc.contributor.author | Marques, Margarida | |
dc.contributor.author | Bourke, Michael J. | |
dc.contributor.author | Macedo, Guilherme | |
dc.date.accessioned | 2024-07-04T11:33:10Z | |
dc.date.available | 2024-07-04T11:33:10Z | |
dc.date.issued | 2023-08 | |
dc.description.abstract | Endoscopic submucosal dissection (ESD) in colorectal lesions is demanding, and a significant rate of non-curative procedures is expected. We aimed to assess the rate of residual lesion after a piecemeal ESD resection, or after an en bloc resection but with positive horizontal margins (local-risk resection-LocRR), for colorectal benign neoplasia. A retrospective multicenter analysis of consecutive colorectal ESDs was performed. Patients with LocRR ESDs for the treatment of benign colorectal lesions with at least one follow-up endoscopy were included. A cohort of en bloc resected lesions, with negative margins, was used as the control. A total of 2255 colorectal ESDs were reviewed; 352 of the ESDs were "non-curative". Among them, 209 were LocRR: 133 high-grade dysplasia and 76 low-grade dysplasia. Ten cases were excluded due to missing data. A total of 146 consecutive curative resections were retrieved for comparison. Compared to the "curative group", LocRRs were observed in lengthier procedures, with larger lesions, and in non-granular LSTs. Recurrence was higher in the LocRR group (16/199, 8% vs. 1/146, 0.7%; p = 0.002). However, statistical significance was lost when considering only en bloc resections with positive horizontal margins (p = 0.068). In conclusion, a higher rate of residual lesion was found after a piecemeal ESD resection, but not after an en bloc resection with positive horizontal margins. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Santos-Antunes J, Pioche M, Ramos-Zabala F, et al. Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study. J Clin Med. 2023;12(16):5356. doi:10.3390/jcm12165356 | pt_PT |
dc.identifier.doi | 10.3390/jcm12165356 | pt_PT |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/10400.16/2998 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | MDPI | pt_PT |
dc.relation.publisherversion | https://doi.org/10.3390/jcm12165356 | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | colorectal lesions | pt_PT |
dc.subject | endoscopic submucosal dissection | pt_PT |
dc.subject | lateral spreading tumor | pt_PT |
dc.subject | local-risk resection | pt_PT |
dc.subject | piecemeal resection | pt_PT |
dc.subject | residual lesion | pt_PT |
dc.title | Risk of Residual Neoplasia after a Local-Risk Resection of Colorectal Lesions by Endoscopic Submucosal Dissection: A Multinational Study | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.conferencePlace | Switzerland | pt_PT |
oaire.citation.issue | 16 | pt_PT |
oaire.citation.startPage | 5356 | pt_PT |
oaire.citation.title | Journal of Clinical Medicine | pt_PT |
oaire.citation.volume | 12 | pt_PT |
person.familyName | Küttner-Magalhães | |
person.givenName | Ricardo | |
person.identifier.ciencia-id | F31A-B091-3D92 | |
person.identifier.orcid | 0000-0002-8522-5756 | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
relation.isAuthorOfPublication | 31c5be90-3d09-4853-8197-c5e03608e482 | |
relation.isAuthorOfPublication.latestForDiscovery | 31c5be90-3d09-4853-8197-c5e03608e482 |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Santos-antunes-2023-Risk-of-residual-neoplasia-after-a-.pdf
- Size:
- 399.11 KB
- Format:
- Adobe Portable Document Format
License bundle
1 - 1 of 1
No Thumbnail Available
- Name:
- license.txt
- Size:
- 1.44 KB
- Format:
- Item-specific license agreed upon to submission
- Description: