Ferrari, FiorenzaPuci, Mariangela ValentinaFerraro, Ottavia EleonoraRomero-González, GregorioHusain-Syed, FaeqRizo-Topete, LiliaSenzolo, MaraLorenzin, AnnaMuraro, EvaBaracca, AntonioSerrano-Soto, MaraMolano Triviño, AlejandraCastro, AnaDe Cal, MassimoCorradi, ValentinaBrendolan, AlessandraScarpa, MartaCarta, Maria RosaGiavarina, DavideBonato, RaffaeleIotti, Giorgio AntonioRonco, Claudio2020-08-212020-08-212019Ferrari F, Puci MV, Ferraro OE, et al. Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit. PLoS One. 2019;14(6):e0217424. Published 2019 Jun 20. doi:10.1371/journal.pone.02174241932-6203http://hdl.handle.net/10400.16/2439AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.engIntensive Care Unitsjournal article10.1371/journal.pone.0217424