Alves da Silva, Joana InêsCaetano, CidalinaPedroto, Isabel2021-05-202021-05-202020-08Alves da Silva JI, Caetano C, Pedroto I. Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn's Disease Patient. GE Port J Gastroenterol. 2020 Aug;27(5):361-363. doi: 10.1159/000505037. Epub 2020 Jan 7. PMID: 32999909; PMCID: PMC7506223.2341-4545http://hdl.handle.net/10400.16/2456Introduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of patients. Case presentation: We report the case of a Crohn's disease patient who developed sialadenitis as an AE to AZA. Discussion and conclusion: To our knowledge this AE has been reported only once in the literature. Sialadenitis is a common disorder and refers to inflammation of a salivary gland. It has many causes, such as bacterial and viral infections, ductal obstruction, and drugs. There are several AEs related to this drug, categorized as dose-dependent and dose-independent. Their knowledge is essential for therapeutic management in IBD, which is already challenging, requiring an individualized approach.engAzathioprineAdverse effectSialadenitisCrohn’s diseasejournal article10.1159/000505037