Martins-da-Silva, AntónioLopes, JoãoRamalheira, JoãoCarvalho, CláudiaCunha, DanielaCosta, Paulo PSilva, M Berta2015-11-022015-11-022014-01-16Rev Neurol 2014; 58 (2): 49-540210-0010http://hdl.handle.net/10400.16/1875The determination of human leukocyte antigen (HLA) class II genotype is widely used to confirm the diagnosis of narcolepsy with or without cataplexy. The HLA genotyping is reliable, easy to perform and reassures the clinician. It is also less invasive than other methodologies and is in accordance with the autoimmune hypothesis for the origin of narcolepsy. AIM. To assess the usefulness of genetic markers (HLA) in the differential diagnosis between different sleep disorders and their relevance in the context of our population.engHLA-DQB1*06:02HypocretinIdiopathic hypersomniaNarcolepsyNarcolepsy with cataplexySleep disordersjournal article