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Browsing by Author "Laranjeira, C."

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  • CHEMOKINE RECEPTOR REPERTOIRE REFLECTS MATURE T-CELL LYMPHOPROLIFERATIVE DISORDER CLINICAL PRESENTATION
    Publication . Moura, J.; Rodrigues, J.; Santos, A.; Teixeira, M.; Queirós, M.; Santos, M.; Gonçalves, M.; Fonseca, S.; Laranjeira, C.; Ribeiro, F.; Acosta, M.; Rodrigues, A.; Júnior, E.; Lima, M.
    The World Health Organisation classification of mature T-cell lymphoproliferative disorders, combines clinical, morphological and immunophenotypic data. The later majorly contributes for the classification, as well as to the understanding of the malignant T-cell behaviour. The fact that T-cell migration is regulated by chemokines should, in theory, enable us to identify tissue tropism and organ involvement by neoplastic Tcells, through monitoring of chemokine receptor surface expression.
    2009Conference object Open access Show more
  • Hemorragia uterina disfuncional na adolescência
    Publication . Laranjeira, C.; Soares, S.; Pereira, E.; Coelho, D.; Ferreira, C.; Peres, S.
    Os problemas menstruais constituem aproximadamente 50% das queixas ginecológicas na adolescência, sendo a hemorragia uterina disfuncional responsável por 90 a 95% dos casos. Trata-se de uma entidade clínica muito frequente nos 2 primeiros anos após a menarca, uma vez que os ciclos menstruais tendem a ser anovulatórios. É um diagnóstico de exclusão, devendo outras possíveis causas ser estudadas: discrasias sanguíneas, complicações de gravidez, endocrinopatias, patologia pélvica e medicamentos. Os autores fazem uma revisão da fisiopatologia, avaliação diagnóstica e tratamento, no sentido de uniformizar atitudes terapêuticas. ABSTRACT: The menstrual disorders constitute about 50% of gynaecological complaints in adolescence, and the dysfunctional uterine bleeding accounts for 90 to 95% of cases. This is a very common clinical entity in the first 2 years after menarche, because the menstrual cycles tend to be anovulatory. It is a diagnosis of exclusion, and other possible causes should be studied: coagulation disorders, complications of pregnancy, endocrinopathies, pelvic pathology and medications. The authors present a review of the pathophysiology, diagnostic evaluation and treatment in order to unify attitudes.
    2008-12Journal article Open access Show more