Browsing by Author "Pinto, I."
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- A importância da Comissão de Proteção Contra RadiaçõesPublication . Monteiro, A.; Machado, C.; Oliveira, F.; Pinto, I.Todos os dias a nível mundial, a radiação ionizante é utilizada para geração de imagens de pacientes, em mais de 10 milhões de procedimentos de radiologia de diagnóstico. O uso crescente de radiação ionizante pode ser visto como um simples aumento do volume de trabalho ou como uma mudança no tipo de procedimentos realizados. O principal objetivo do controlo da radiação é garantir que as doses recebidas pelos profissionais não excedam os valores estabelecidos pela decreto de lei nº 222/2008 permitindo através da avaliação sistemática das doses recebidas definir as estratégias de otimização sempre que necessário. A Comissão de Proteção Contra Radiações (CPCR) do Centro Hospital do Porto (CHP) é uma equipa multidisciplinar, criada em 2006 e integrada no Departamento da Qualidade com o intuito de garantir que todas as normas de proteção radiológica (justificação, otimização e limitação de dose) sejam cumpridas.
- Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosisPublication . Simão, M.; Camacho, A.; Ostertag, A.; Cohen-Solal, M.; Pinto, I.; Porto, G.; Hang Korng, E.; Cancela, M.Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood. The main objective of this study was to investigate the role of dietary iron on osteoporosis, using as biological model the Hfe-KO mice, which have a systemic iron overload. We showed that these mice show an increased susceptibility for developing a bone loss phenotype compared to WT mice, which can be exacerbated by an iron rich diet. The dietary iron overload caused an increase in inflammation and iron incorporation within the trabecular bone in both WT and Hfe-KO mice. However, the osteoporotic phenotype was only evident in Hfe-KO mice fed the iron-enriched diet. This appeared to result from an imbalance between bone formation and bone resorption driven by iron toxicity associated to Hfe-KO and confirmed by a decrease in bone microarchitecture parameters (identified by micro-CT) and osteoblast number. These findings were supported by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype. In WT mice the iron rich diet was not enough to promote a bone loss phenotype, essentially due to the concomitant depression of bone resorption observed in those animals. In conclusion the dietary challenge influences the development of osteoporosis in the HH mice model thus suggesting that the iron content in the diet may influence the osteoporotic phenotype in systemic iron overload conditions.