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- Study protocol: the DOse REsponse Multicentre International collaborative initiative (DO-RE-MI).Publication . Kindgen-Milles, D.; Journois, D.; Fumagalli, R.; Vesconi, S.; Maynar, J.; Marinho, A.; Bolgan, I.; Brendolan, A.; Formica, M.; Livigni, S.; Maio, M.; Marchesi, M.; Mariano, F.; Monti, G.; Moretti, E.; Silengo, D.; Ronco, C.We found 1 article by title matching your search: Crit Care. 2005 Aug;9(4):R396-406. Epub 2005 Jun 14. Study protocol: the DOse REsponse Multicentre International collaborative initiative (DO-RE-MI). Kindgen-Milles D, Journois D, Fumagalli R, Vesconi S, Maynar J, Marinho A, Bolgan I, Brendolan A, Formica M, Livigni S, Maio M, Marchesi M, Mariano F, Monti G, Moretti E, Silengo D, Ronco C. Anesthesiology Clinic, University of Düsseldorf, Germany. Kindgen-Milles@med.uni-duesseldorf.de Abstract INTRODUCTION: Current practices for renal replacement therapy in intensive care units (ICUs) remain poorly defined. The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) will address the issue of how the different modes of renal replacement therapy are currently chosen and performed. Here, we describe the study protocol, which was approved by the Scientific and Steering Committees. METHODS: DO-RE-MI is an observational, multicentre study conducted in ICUs. The primary end-point will be the delivered dose of dialysis, which will be compared with ICU mortality, 28-day mortality, hospital mortality, ICU length of stay and number of days of mechanical ventilation. The secondary end-point will be the haemodynamic response to renal replacement therapy, expressed as percentage reduction in noradrenaline (norepinephrine) requirement. Based on the the sample analysis calculation, at least 162 patients must be recruited. Anonymized patient data will be entered online in electronic case report forms and uploaded to an internet website. Each participating centre will have 2 months to become acquainted with the electronic case report forms. After this period official recruitment will begin. Patient data belong to the respective centre, which may use the database for its own needs. However, all centres have agreed to participate in a joint effort to achieve the sample size needed for statistical analysis. CONCLUSION: The study will hopefully help to collect useful information on the current practice of renal replacement therapy in ICUs. It will also provide a centre-based collection of data that will be useful for monitoring all aspects of extracorporeal support, such as incidence, frequency, and duration. PMID: 16137353 [PubMed - indexed for MEDLINE]PMCID: PMC1269446Free PMC Article Images from this publication.See all images (4) Free text Figure 1Flowchart of the DO-RE-MI observational study. All incident patients admitted to the intensive care unit (ICU) and requiring renal replacement therapy (RRT) will be followed up during RRT. At discharge, primary and secondary end-points will be recorded. All data will be entered in electronic case re...Study protocol: The DOse REsponse Multicentre International collaborative initiative (DO-RE-MI)Crit Care. 2005;9(4):R396-R406.
- Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviorsPublication . Cerqueira, J.; Pêgo, J.; Taipa, R.; Bessa, J.; Almeida, O.; Sousa, N.Imbalances in the corticosteroid milieu have been implicated in several neuropsychiatric disorders, including depression and schizophrenia. Prefrontal cortex (PFC) dysfunction is also a hallmark of these conditions, causing impairments in executive functions such as behavioral flexibility and working memory. Recent studies have suggested that the PFC might be influenced by corticosteroids released during stress. To test this possibility, we assessed spatial working memory and behavioral flexibility in rats submitted to chronic adrenalectomy or treatment with corticosterone (25 mg/kg) or the synthetic glucocorticoid dexamethasone (300 g/kg); the behavioral analysis was complemented by stereological evaluation of the PFC (prelimbic, infralimbic, and anterior cingulate regions), the adjacent retrosplenial and motor cortices, and the hippocampal formation. Dexamethasone treatment resulted in a pronounced impairment in working memory and behavioral flexibility, effects that correlated with neuronal loss and atrophy of layer II of the infralimbic, prelimbic, and cingulate cortices. Exposure to corticosterone produced milder impairments in behavioral flexibility, but not in working memory, and reduced the volume of layer II of all prefrontal areas. Interestingly, adrenalectomy-induced deleterious effects only became apparent on the reverse learning task and were not associated with structural alterations in the PFC. None of the experimental procedures influenced the morphology of retrosplenial or motor cortices, but stereological measurements confirmed previously observed effects of corticosteroids on hippocampal structure. Our results describe, for the first time, that imbalances in the corticosteroid environment can induce degeneration of specific layers of the PFC; these changes appear to be the morphological correlate of corticosteroid-induced impairment of PFC-dependent behavior(s)