Browsing by Issue Date, starting with "2007-03"
Now showing 1 - 10 of 14
Results Per Page
Sort Options
- Lesões hipopigmentadas na criançaPublication . Coutinho, P.; Machado, S.As hipopigmentações cutâneas nas crianças são um motivo frequente de consulta em dermatologia pediátrica. Com um diagnóstico essencialmente clínico, acarretam por vezes alguma dificuldade no diagnóstico diferencial e podem indiciar importantes doenças multissistémicas. Neste artigo faz-se uma abordagem das principais lesões hipopigmentadas das crianças, dividindo-as de acordo com a sua extensão e altura de aparecimento, e descrevendo sucintamente a sua principal etiologia, clínica, diagnóstico diferencial e terapêutica. ABSTRACT Disorders of hypopigmentation are frequent in a paediatric dermatology consultation. As diagnosis is essentially clinical, differential diagnosis may be difficult. Selected diseases have signature skin findings which can identify a multysistemic disorder. In this article, the principal hypopigmented lesions in children are reviewed considering history and physical examination, specially the distribution of the lesions, age of onset, aetiology, clinical manifestations, differential diagnosis and therapy.
- Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus.Publication . PEDROSO, S.L.; Martins, La Salete; SOUSA, S.; REIS, A.; DIAS, L.; HENRIQUES, A.C.; SARMENTO, A.M.; CABRITA, A.Transpl Int. 2007 Mar;20(3):291-6. Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus. Pedroso SL, Martins LS, Sousa S, Reis A, Dias L, Henriques AC, Sarmento AM, Cabrita A. Nephrology Department, Hospital Geral de Santo António, Porto, Portugal. sofiapedroso@sapo.pt Abstract The aim of our paper is to describe an unusual pulmonary toxicity of sirolimus (SRL) in a kidney transplant recipient. We present a 34-year-old woman with a second renal transplantation, complicated with steroid-resistant acute rejection and chronic allograft dysfunction. Two years after initiating SRL, she presented complaints of progressive dyspnoea, nonproductive cough, chest pain and low-grade fever of 1 month duration. She had chronic allograft nephropathy and slight elevation of lactic dehydrogenase levels. After exclusion of common reasons of this condition, a computed tomography (CT) of the thorax and bronchoscopy was performed, revealing ground-glass opacification with polygonal shapes on CT and an opaque appearance with numerous macrophages on bronchoalveolar lavage. The alveolar macrophages stained positive by Periodic acid-Schiff. Diagnosis of pulmonary alveolar proteinosis (PAP) was made and drug-induced toxicity was suspected. SRL was withdrawn with marked improvement in the patients' clinical and radiological status. PAP resolved within 3 months without further therapy. PAP is a very rare complication of SRL therapy with only a few cases described. Withdrawal of SRL with conversion to another immunosuppressant seems to be an appropriate procedure in this condition. PMID: 17291222 [PubMed - indexed for MEDLINE
- Imagens: pneumonia do lobo da veia ázigosPublication . Cristóvão, C.; David, C.; Preto, L.
- Identification of a new mtDNA mutation (14724G>A) associated with mitochondrial leukoencephalopathyPublication . PEREIRA, C.; NOGUEIRA, C.; BARBOT, C.; TESSA, A.; SOARES, C.; FATTORI, F.; GUIMARÃES, A.; SANTORELLI, F.M.; VILARINHO, L.Biochem Biophys Res Commun. 2007 Mar 23;354(4):937-41. Epub 2007 Jan 23. Identification of a new mtDNA mutation (14724G>A) associated with mitochondrial leukoencephalopathy. Pereira C, Nogueira C, Barbot C, Tessa A, Soares C, Fattori F, Guimarães A, Santorelli FM, Vilarinho L. Instituto de Genética Médica Jacinto de Magalhães, Praça Pedro Nunes, 88, 4099-028 Porto, Portugal. Abstract We report a novel 14724G>A mutation in the mitochondrial tRNA glutamic acid gene in a 4-year-old boy with myopathy and leukoencephalopathy. A muscle biopsy showed cytochrome c oxidase-negative ragged-red fibers and biochemical analysis of the respiratory chain enzymes in muscle homogenate revealed partial complex I and complex IV deficiencies. The mutation, which affects the dihydrouridine arm at a conserved site, was nearly homoplasmic in muscle and heteroplasmic in blood DNA of the proband, but it was absent in peripheral leukocytes from the asymptomatic mother, sister, and two maternal aunts, suggesting that it arose de novo. This report proposes to look for variants in the mitochondrial genome when dealing with otherwise undetermined leukodystrophies of childhood. PMID: 17266923 [PubMed - indexed for MEDLINE]
- Hemangioma da pálpebra em recém-nascido pré-termoPublication . Martins, C.; Caldeira, T.; Ferreira, E.; Varandas, R.; Pinto, R.Os hemangiomas são os tumores benignos mais frequentes na infância e em especial nos recém-nascidos de pré-termo. Habitualmente aparecem nas primeiras semanas de vida e a fase proliferativa pode ser rápida. Geralmente regridem espontaneamente, mas dependendo da localização e do volume pode ser necessário o tratamento farmacológico e/ou cirúrgico. Os autores apresentam o caso clínico de um recém-nascido de pré-termo (28 semanas gestacionais) a quem ao oitavo dia de vida aparece um hemangioma plano da pálpebra superior direita. Ao longo do internamento assistiu-se a um rápido crescimento do mesmo com ptose total do olho. O risco de ambliopia levou à necessidade de intervenção terapêutica com corticoterapia sistémica e intra-lesional, tendo sido a resposta clínica favorável. Actualmente, aos 7 meses, a lactente apresenta um exame oftalmológico normal. O tratamento atempado foi essencial para a redução do hemangioma e do risco de ambliopia. ABSTRACT Haemangioma is the most frequent benign tumour in infancy, especially in premature neonates. It usually appears in the first weeks of life and may proliferate quickly. Normally it diminishes spontaneously but, depending on the location and the volume, pharmacological treatment or surgery may be necessary. The authors report a case of a premature neonate (28 gestational weeks) aged 8 days, presenting a plan haemangioma located in the superior right eyelid. During the hospital stay, we verified a rapid growth of the haemangioma with total ptosis. The risk of ambliopy imposed therapeutic intervention associated with systemic and intra-lesional corticotherapy, with good clinic response. At the aged of seven months, the infant has a normal ophthalmologic exam. The precocity of the treatment was essential to the reduction of the haemangioma and the risk of ambliopy.
- Caso estomatológico: mordida abertaPublication . Amorim, J.
- Pseudo-quisto abdominalPublication . Sousa, M.; Costa, J.; Alves, A.; Salgado, M.Apresentamos o caso clínico de uma criança de 5 anos de idade, sexo masculino, com hidrocefalia secundária a quisto porencefálico congénito, com sistema de derivação ventriculo-peritoneal (DVP) do LCR desde os 12 meses de idade, que se complicou, 4 anos depois, de pseudo-quisto abdominal (PQA), em cuja cultura do conteúdo se desenvolveu uma Brucella spp. A revisão da literatura sobre peritonite/ ascite por Brucella, mostrou tratarem- se de situações muito raras, ocorrendo mais em adultos com doença grave subjacente ou em indivíduos com catéter intra-abdominal com sistemas de DVP. Na literatura internacional estão publicados cerca de 20 casos clínicos de ascite / peritonite por Brucella. Contudo não encontrámos nenhuma outra descrição de infecção dum PQA por Brucella. ABSTRACT We present a case of a five year-old boy with hydrocephaly secondary to a congenital porencephalic cyst, with ventricular-peritoneal shunt of cerebral-spinal fluid, since the age of 12 months. He developed, 4 years later, an abdominal pseudo-cyst. The culture of the pseudo-cyst’s content was positive for Brucella spp. The review of literature shows that peritonitis / ascitis caused by Brucella, is rare, and takes place in serious ill adults or in individuals with intra-abdominal catheter of ventricular-peritoneal shunt. The authors found 20 cases of peritonitis / ascitis caused by Brucella, in the international literature, however, we have not found any description of an abdominal pseudo-cyst infection by this bacteria.
- Caso endoscópico: parasitose intestinalPublication . Pereira, F.
- Bladder exstrophy adenocarcinoma in an adult woman. Case reportPublication . PALACIOS, A.; VERSOS, R.; MASSÓ, P.; CAVADAS, V.; SOARES, J.; MARCELO, F.Arch Esp Urol. 2007 Mar;60(2):198-200. [Bladder exstrophy adenocarcinoma in an adult woman. Case report] [Article in Spanish] Palacios A, Versos R, Massó P, Cavadas V, Soares J, Marcelo F. Servicio de Urología, Hospital Geral de Santo Antonio, Porto, Portugal. aphmmx5@hotmail.com Abstract OBJECTIVE: To report a clinical case of bladder exstrophy adenocarcinoma. METHODS: 57-year-old female presenting with a hypogastric mass. The biopsy of the mass revealed bladder adenocarcinoma. We performed radical cystectomy. RESULTS: Pathologic study was compatible with moderately differentiated adenocarcinoma. CONCLUSIONS: After six months of follow-up patient is disease-free. PMID: 17484491 [PubMed - indexed for MEDLINE