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- Infantile myofibromatosis - a clinical and pathological diagnostic challengePublication . Mota, F.; Machado, S.; Moreno, F.; Barbosa, T.; Selores, M.Infantile myofibromatosis is a rare disorder of fibroblastic/myofibroblastic proliferation and represents the most frequent type of mesenchymal tumor in the neonatal period and primary infancy.Three clinical types have been described: solitary, multicentric, and generalized (with visceral involvement). A correct characterization of the histopathology is essential to diagnose these neoplasias in early infancy. We present a case of multicentric infantile myofibromatosis with regression over time.