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Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis

2014Journal article Open access
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dc.contributor.authorRocha, A.
dc.contributor.authorBravo, F.
dc.contributor.authorBeirão, I.
dc.contributor.authorVizcaíno, J.
dc.contributor.authorOliveira, J.
dc.contributor.authorLobato, L.
dc.date.accessioned2015-01-07T19:07:33Z
dc.date.available2015-01-07T19:07:33Z
dc.date.issued2014
dc.description.abstractAim: The detection and prognosis of nephropathy in transthyretin amyloidosis depends on albuminuria and renal function. Knowing that urinary levels of alpha-1 microglobulin and beta-2 microglobulin reflect tubular dysfunction while urinary alpha-2 macroglobulin implies glomerular damage, we decide investigate the diagnostic value of these markers in the patients with transthyretin amyloidosis. Methods: Serum and urinary samples collected from 30 patients and 11 asymptomatic carriers were tested for alpha-1 microglobulin, beta-2 microglobulin, alpha-2 macroglobulin, albumin, creatinine and cystatin C. Results: Pathological urinary alpha-1 microglobulin was detected in 17 patients, beta-2 microglobulin in 6 and alpha-2 macroglobulin in 5; 5 patients had albuminuria (mg/g creatinine) 30-300 and in 20 patients values >300 were present. Asymptomatic carriers did not present pathological excretion of these biomarkers and albuminuria was >30 in 1 individual. The excretion rates of alpha-1 microglobulin and beta-2 microglobulin were positively correlated with albuminuria (P<0.001), serum creatinine (P<0.05) and cystatin C (P<0.001). Urinary alpha-2 macroglobulin was almost exclusively found in the presence of albuminuria, although their levels do not correlate. Conclusion: Urinary biomarkers emerge as a potential approach to detect renal disease but unexpectedly, urinary alpha-2 macroglobulin was not a marker of the severity of albuminuria.por
dc.identifier.citationRocha A, Bravo F, Beirão I, Vizcaíno J, Oliveira JC, et al. (2014) Urinary Biomarkers for Kidney Disease in ATTR Amyloidosis. J Nephrol Ther 4: 181. doi:10.4172/2161-0959.1000181por
dc.identifier.doi10.4172/2161-0959.1000181
dc.identifier.urihttp://hdl.handle.net/10400.16/1732
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherOMICS Publishing Grouppor
dc.relation.publisherversionhttp://omicsonline.org/open-access/urinary-biomarkers-for-kidney-disease-in-attr-amyloidosis-2161-0959.1000181.php?aid=32195por
dc.subjectTransthyretinpor
dc.subjectAmyloidpor
dc.subjectLow molecular weight proteinspor
dc.subjectKidneypor
dc.subjectProximal tubulespor
dc.titleUrinary Biomarkers for Kidney Disease in ATTR Amyloidosispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Nephrology & Therapeuticspor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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