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[Chorioamnionitis and neonatal morbidity]
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Advisor(s)
Abstract(s)
CHORIOAMNIONITIS AND NEONATAL MORBIDITY
Introduction - Several studies highlight the association between perinatal infection/
inflammation and neonatal morbidity, mainly bronchopulmonary dysplasia and
periventricular leukomalacia.
Aim – To evaluate the role of histological chorioamnionitis on the overall morbidity of
preterm newborns.
Methods – A retrospective study on preterm newborns less than 34 weeks gestational
age at birth, and respective mothers, at three tertiary medical centers (Hospital de São
João, Maternidade Júlio Dinis and Centro Hospitalar de Vila Nova de Gaia) in the north
of Portugal, between January 2001 and December 2002.
We evaluated the association between histological chorioamnionitis and the overall
neonatal morbidity. The association between histological chorioamnionitis and acute
(respiratory distress syndrome) and chronic (bronchopulmonary dysplasia) lung
damage was also evaluated in the subgroup of less than 1000 g birthweight preterm
neonates.
Results – 452 [ M 253 / F 217; birthweight 1440 (515 – 2620) g; gestational age 31 (23 –
33) weeks] preterm newborns were included. The association between histological
chorioamnionitis and the overall neonatal morbidity was: respiratory distress syndrome
OR 1,5 (95% CI 0,94 – 2,31); bronchopulmonary dysplasia OR 2,6 (95% CI 1,16 – 6,03);
patent ductus arteriosus OR 2,5 (95% CI 1,17 – 5,44); sepsis OR 1,2 (95% CI 0,9 – 2,13);
necrotizing enterocolitis OR 1,4 (95% CI 0,9 – 1,76); intraventricular hemorrhage grades
III-IV OR 2,5 (1,20 – 5,11); cystic periventricular leukomalacia OR 3,0 (1,5 – 6,07);
retinopathy of prematurity OR 1,4 (95% CI 0,8 – 1,35). The association adjusted to
birthweight and gestational age was: bronchopulmonary dysplasia OR 1,2 (95% CI
0,51 – 2,95); patent ductus arteriosus OR 0,9 (95% CI 0,4 – 2,35); intraventricular
hemorrhage grades III-IV OR 0,9 (95% CI 0,39 – 2,28); cystic periventricular leukomalacia
OR 2,2 (95% CI 1,03 – 4,61). The association between histological chorioamnionitis
and lung damage in the subgroup of less than 1000 g birthweight preterm neonates
was: respiratory distress syndrome OR 0,23 (95% CI 0,01 – 2,51); bronchopulmonary
dysplasia OR 1,61 (95% CI 0,38 – 6,97).
Conclusion – This study confirms the association between histological chorioamnionitis
and cystic periventricular leukomalacia of the preterm newborn.
Description
Keywords
corioamnionite chorioamnionitis recém-nascido morbidity leucomalácia periventricular morbilidade newborn preterm periventricular leukomalacia
Citation
Acta Med Port. 2006 May‐Jun;19(3):207‐12. Epub 2006 Sep 7. Portuguese. PMID: 17234081
Publisher
Centro Editor Livreiro da Ordem dos Médicos