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Clinical performance of an infliximab rapid quantification assay

2017-09Journal article Open access
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dc.contributor.authorMagro, F.
dc.contributor.authorAfonso, J.
dc.contributor.authorLopes, S.
dc.contributor.authorCoelho, R.
dc.contributor.authorGonçalves, R.
dc.contributor.authorCaldeira, P.
dc.contributor.authorLago, P.
dc.contributor.authorSousa, H.
dc.contributor.authorRamos, J.
dc.contributor.authorGonçalves, A.
dc.contributor.authorMinistro, P.
dc.contributor.authorRosa, I.
dc.contributor.authorMeira, T.
dc.contributor.authorAndrade, P.
dc.contributor.authorSoares, J.
dc.contributor.authorCarvalho, D.
dc.contributor.authorSousa, P.
dc.contributor.authorVieira, A.
dc.contributor.authorLopes, J.
dc.contributor.authorDias, C.
dc.contributor.authorGeboes, K.
dc.contributor.authorCarneiro, F.
dc.date.accessioned2018-10-25T14:40:48Z
dc.date.available2018-10-25T14:40:48Z
dc.date.issued2017-09
dc.description.abstractBACKGROUND: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. METHODS: This manuscript describes a prospective cohort study involving 110 ulcerative colitis (UC) patients on the maintenance phase of IFX. IFX trough levels were quantified using a rapid quantification assay and a commonly-used reference kit. RESULTS: Irrespective of the assay used to measure IFX, its through levels were statistically different between patients with and without endoscopic remission (Mayo endoscopic score = 0), as well as between patients stratified by their faecal calprotectin (FC) levels. Despite the fact that the two methods correlated well with each other [Spearman's rank correlation coefficient = 0.843, p < 0.001; intraclass correlation coefficients = 0.857, 95% confidence interval (CI): 0.791-0.903], there was a discernible systematic variation; values obtained with the reference kit were on average 2.62 units higher than those obtained with the rapid assay. Notwithstanding, 3 µg/ml was shown to be an acceptable cut-off to assess endoscopic status and inflammatory burden levels using both assays. The percentage of patients that had a positive outcome when the IFX concentration measured by the rapid assay ranked above 3 µg/ml was 88% both for a Mayo endoscopic score ⩽ 1 and for an FC concentration <250 µg/g. CONCLUSIONS: Based on this study, we concluded that using the rapid IFX assessment system with a 3 µg/ml threshold is a reliable alternative to the time-consuming enzyme-linked immunosorbent assays in patients on the maintenance phase of IFX.pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese IBD Group (GEDII, Grupo de Estudo da Doença Inflamatória Intestinal)pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTherap Adv Gastroenterol. 2017 Sep;10(9):651-660pt_PT
dc.identifier.doi10.1177/1756283X17722916pt_PT
dc.identifier.issn1756-283X
dc.identifier.issn1756-2848
dc.identifier.urihttp://hdl.handle.net/10400.16/2235
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttp://journals.sagepub.com/doi/abs/10.1177/1756283X17722916?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&pt_PT
dc.subjectinfliximabpt_PT
dc.subjecttherapeutic windowpt_PT
dc.subjectulcerative colitispt_PT
dc.titleClinical performance of an infliximab rapid quantification assaypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.endPage660pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage651pt_PT
oaire.citation.titleTherapeutic Advances in Gastroenterologypt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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