Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy

Veiga, A.; Costa, A.; Taipa, Ri.; Guimarães, A.; Melo-Pires, M.

Publication

Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy

2015Journal article

dc.contributor.author	Veiga, A.
dc.contributor.author	Costa, A.
dc.contributor.author	Taipa, Ri.
dc.contributor.author	Guimarães, A.
dc.contributor.author	Melo-Pires, M.
dc.date.accessioned	2016-08-01T10:44:45Z
dc.date.available	2016-08-01T10:44:45Z
dc.date.issued	2015
dc.description.abstract	INTRODUCTION: Leprosy is still one of the most frequent causes of peripheral neuropathy. Although regarded as eradicated in Portugal, is still documented in neuropathological study of patients with clinical peripheral neuropathy without proper diagnosis.	pt_PT
dc.description.abstract	MATERIAL AND METHODS: Review of the cases of Hansen disease neuropathy diagnosed in Neuropathology Unit of Centro Hospitalar do Porto between 1978 and 2013, atending to gender, age, clinical manifestations and neuropathological findings.	pt_PT
dc.description.abstract	RESULTS: Twenty one patients were identified with neuropathological diagnosis of Hansenâs disease neuropathy, predominantly male. The mean age at diagnosis was 52 years, and sensory symptoms predominate as neurological manifestation of disease. Interval between symptoms and diagnosis was 1-38 years. In most nerve samples tuberculoid type of disease was identified. Bacilli were detected in skin and nerve in 44% of cases.	pt_PT
dc.description.abstract	DISCUSSION: Mononeuritis is the most common presentation of leprosy but other clinical manifestations are possible, including skin lesions. Infection with M. leprae injures myelinated and unmyelinated fibres, with replacement of nerve tissue by collagen fibrosis. The diagnosis of leprosy is only achieved by neuropathological study of skin lesions and / or peripheral nerve, supported by the identification of the bacillus.	pt_PT
dc.description.abstract	CONCLUSION: Hansen disease remains a public health problem in tropical areas and, although rare, still described in Western countries reason why should still be considered as a diagnostic possibility in the investigation of peripheral neuropathy.	pt_PT
dc.identifier.citation	Acta Med Port. 2015 May-Jun;28(3):329-32.	pt_PT
dc.identifier.issn	1646-0758
dc.identifier.uri	http://hdl.handle.net/10400.16/1987
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Centro Editor Livreiro da Ordem dos Médicos	pt_PT
dc.relation.publisherversion	http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/5876/4361	pt_PT
dc.title	Hansen Neuropathy: Still a Possible Diagnosis in the Investigation of a Peripheral Neuropathy	pt_PT
dc.title.alternative	Neuropatia da Doença de Hansen: Um Diagnóstico a Considerar na Investigação da Neuropatia Periférica	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.conferencePlace	Portugal	pt_PT
oaire.citation.endPage	332	pt_PT
oaire.citation.issue	3	pt_PT
oaire.citation.startPage	329-32	pt_PT
oaire.citation.title	Acta Médica Portuguesa	pt_PT
oaire.citation.volume	28	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT