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The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases

dc.contributor.authorBettencourt, A.
dc.contributor.authorCarvalho, C.
dc.contributor.authorLeal, B.
dc.contributor.authorBrás, S.
dc.contributor.authorLopes, D.
dc.contributor.authorMartins da Silva, A.
dc.contributor.authorSantos, E.
dc.contributor.authorTorres, T.
dc.contributor.authorAlmeida, I.
dc.contributor.authorFarinha, F.
dc.contributor.authorBarbosa, P.
dc.contributor.authorMarinho, A.
dc.contributor.authorSelores, M.
dc.contributor.authorCorreia, J.
dc.contributor.authorVasconcelos, C.
dc.contributor.authorCosta, P.
dc.contributor.authorda Silva, B.
dc.date.accessioned2016-04-11T10:46:07Z
dc.date.available2016-04-11T10:46:07Z
dc.date.issued2015
dc.description.abstractAutoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background, with the MHC region playing a major role. We genotyped for HLA-DRB1 locus 1228 patients with AIDs-213 with Systemic Lupus Erythematosus (SLE), 166 with Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 with Rheumatoid Arthritis (RA), 67 with Systemic Sclerosis (SSc), 536 with Multiple Sclerosis (MS), and 93 with Myasthenia Gravis (MG) and 282 unrelated controls. We confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) and HLA-DRB1(∗)03 (OR = 1.81) alleles with MS, HLA-DRB1(∗)03 with SLE (OR = 2.49), HLA-DRB1(∗)01 (OR = 1.79) and HLA-DRB1(∗)04 (OR = 2.81) with RA, HLA-DRB1(∗)07 with Ps + PsA (OR = 1.79), HLA-DRB1(∗)01 (OR = 2.28) and HLA-DRB1(∗)08 (OR = 3.01) with SSc, and HLA-DRB1(∗)03 with MG (OR = 2.98). We further observed a consistent negative association of HLA-DRB1(∗)13 allele with SLE, Ps + PsA, RA, and SSc (18.3%, 19.3%, 16.3%, and 11.9%, resp., versus 29.8% in controls). HLA-DRB1(∗)13 frequency in the AIDs group was 20.0% (OR = 0.58). Although different alleles were associated with particular AIDs, the same allele, HLA-DRB1(∗)13, was underrepresented in all of the six diseases analysed. This observation suggests that this allele may confer protection for AIDs, particularly for systemic and rheumatic disease. The protective effect of HLA-DRB1(∗)13 could be explained by a more proficient antigen presentation by these molecules, favouring efficient clonal deletion during thymic selection.pt_PT
dc.identifier.citationJ Immunol Res. 2015;2015:948723pt_PT
dc.identifier.doi10.1155/2015/948723pt_PT
dc.identifier.issn2314-7156
dc.identifier.urihttp://hdl.handle.net/10400.16/1917
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttp://www.hindawi.com/journals/jir/2015/948723/pt_PT
dc.titleThe Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEgyptpt_PT
oaire.citation.titleJournal of Immunology Researchpt_PT
oaire.citation.volume2015pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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