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Olfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunction

2023Journal article Open access
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dc.contributor.authorSousa, Francisco Alves De
dc.contributor.authorTarrio, João
dc.contributor.authorSousa-Machado, André
dc.contributor.authorCosta, Joana Raquel
dc.contributor.authorPinto, Catarina
dc.contributor.authorNóbrega Pinto, Ana
dc.contributor.authorMoreira, Bruno
dc.contributor.authorMeireles, Luís
dc.date.accessioned2024-07-04T13:43:51Z
dc.date.available2024-07-04T13:43:51Z
dc.date.issued2023
dc.description.abstractIntroduction: To date, little is known about predisposing factors for persistent COVID-19-induced olfactory dysfunction (pCIOD). The objective was to determine whether olfactory cleft (OC) measurements associate with pCIOD risk. Material and methods: Three subgroups were recruited: group A included patients with pCIOD, group B included patients without olfactory dysfunction following SARS-CoV-2 infection (ntCIOD), and group C consisted in controls without past history of SARS-CoV-2 infection (noCOVID-19). Olfactory perception threshold (OPT) and visual analog scale for olfactory impairment (VAS-olf) were obtained. OC measurements were obtained through computed tomography scans. Results were subsequently compared. Results: A total of 55 patients with a mean age of 39 ± 10 years were included. OPT was significantly lower in pCIOD patients (group A: 4.2 ± 2.1 vs. group B: 12.3 ± 1.8 and group C: 12.2 ± 1.5, p < 0.001). VAS-olf was significantly higher in pCIOD (group A: 6 ± 2.6 vs. group B: 1.7 ± 1.6 and group C: 1.6 ± 1.5, p < 0.001). OC length was significantly higher in group A (42.8 ± 4.6) compared to group B (39.7 ± 3.4, p = 0.047) and C (39.8 ± 4, p = 0.037). The odd of pCIOD occurring after COVID-19 infection increased by 21% (95% CI [0.981, 1.495]) for a one unit (mm) increase in OC length. The odd of pCIOD occurring was 6.9 times higher when OC length >40 mm. Conclusion: Longer OC may be a predisposing factor for pCIOD. This study is expected to encourage further research on OC morphology and its impact on olfactory disorders.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves de Sousa F, Tarrio J, Sousa Machado A, et al. Olfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunction. ORL J Otorhinolaryngol Relat Spec. 2023;85(3):119-127. doi:10.1159/000527141pt_PT
dc.identifier.doi10.1159/000527141pt_PT
dc.identifier.issn0301-1569
dc.identifier.issn1423-0275
dc.identifier.urihttp://hdl.handle.net/10400.16/3000
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKargerpt_PT
dc.relation.publisherversionhttps://doi.org/10.1159/000527141pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectHyposmiapt_PT
dc.subjectLengthpt_PT
dc.subjectOlfactory cleftpt_PT
dc.subjectOlfactory dysfunctionpt_PT
dc.titleOlfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceSwitzerlandpt_PT
oaire.citation.endPage127pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage119pt_PT
oaire.citation.titleORLpt_PT
oaire.citation.volume85pt_PT
person.familyNameSousa
person.familyNameTarrio
person.familyNameSousa-Machado
person.familyNameNóbrega Pinto
person.givenNameFrancisco Alves de
person.givenNameJoão
person.givenNameAndré
person.givenNameAna
person.identifier.orcid0000-0003-4113-3259
person.identifier.orcid0000-0003-0091-1413
person.identifier.orcid0000-0002-8877-8014
person.identifier.orcid0000-0001-7990-5491
person.identifier.ridHIR-6257-2022
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication6d0cf218-638a-4b17-8bdf-30203de52429
relation.isAuthorOfPublication93e6d1bc-29b2-439c-b7ca-8c35cab1895a
relation.isAuthorOfPublicationc0f5906f-a70f-4f92-81af-842a6e8e46db
relation.isAuthorOfPublication9d9aae96-9ea0-4ec8-90de-af9bd8406f68
relation.isAuthorOfPublication.latestForDiscovery6d0cf218-638a-4b17-8bdf-30203de52429

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