Publication
Familial clustering of migraine: further evidence from a Portuguese study
| dc.contributor.author | Lemos, C. | |
| dc.contributor.author | Castro, M. | |
| dc.contributor.author | Barros, J. | |
| dc.contributor.author | Sequeiros, J. | |
| dc.contributor.author | Pereira-Monteiro, J. | |
| dc.contributor.author | Mendonça, D. | |
| dc.contributor.author | Sousa, A. | |
| dc.date.accessioned | 2011-07-11T16:06:33Z | |
| dc.date.available | 2011-07-11T16:06:33Z | |
| dc.date.issued | 2009-03 | |
| dc.description.abstract | Abstract OBJECTIVE: Our aim was to evaluate familial aggregation of migraine in a large group of Portuguese families, and to assess if familial aggregation differs between MA and MO. METHODS: Familial aggregation was evaluated by estimating relative risk (RR) of migraine in 143 first-degree relatives of 50 probands with MA, in 196 first-degree relatives of 94 probands with MO and also in proband's spouses. Probands were enrolled in the study from a clinical sample and a population sample was used as reference. RESULTS: A significantly increased risk of migraine was found in both first-degree relatives of MO probands (RR = 3.7; 95% CI: 3.2-4.3) and of MA probands (RR = 3.6; 95% CI: 3.1-4.3), comparatively to the general population. Risk for spouses was not increased. First-degree relatives of MA probands and MO probands had a significantly increased risk of both MA and MO compared to the general population. In the group of MA probands, RR of MA in first-degree relatives reached a significant 4-fold increase when compared with RR of MO (RR(MA|MA) = 12.2, 95%CI: 7.7-19.5; RR(MO|MA) = 3.1, 95%CI: 2.5-3.8), while, in the group of MO probands, RR of MA was not significantly increased when compared with RR of MO (RR(MA|MO) = 5.3, 95%CI: 3.1-9.2; RR(MO|MO) = 4.0, 95%CI: 3.5-4.7). CONCLUSIONS: The present study focus on familial aggregation of migraine in a Portuguese population. Our results demonstrate a substantial familial risk of migraine with evidence of both common and specific etiologic mechanisms for either migraine subtypes. | por |
| dc.identifier.citation | Headache. 2009 Mar;49(3):404-11 | por |
| dc.identifier.issn | 0017-8748 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/738 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Wiley-Blackwell | por |
| dc.title | Familial clustering of migraine: further evidence from a Portuguese study | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 11 | por |
| oaire.citation.issue | 49(3) | por |
| oaire.citation.startPage | 404 | por |
| oaire.citation.title | Headache | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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