Loading...
Publication
Using the post‐operative quality recovery scale to evaluate recovery with different neuromuscular blocking reversal agentsin the Portuguese population ‐ interim analysis results: 1AP3‐8
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 507.46 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Background and Goal of Study: Post-operative Quality Recovery Scale
(PQRS), is the first scale evaluating several domains of postoperative recovery.
The objectives of this study were to compare overal and physiologic, cognitive,
and functional domains of post-operative recovery af ter elective surgical
procedures using neostigmine or sugammadex as neuromuscular blocking
(NMB) reversal agents, to validate the use of PQRS in the Portuguese
population and to objectively assess muscular strength recovery.
Materials and Methods: Prospective multicenter observational study
comparing postoperative recovery between 2 cohorts of 50 adult patients
submitted to elective surgical procedures with general anesthesia using
Nondepolarizing Muscle Relaxants and NMB reversal with neostigmine or
sugammadex. Measurements obtained using Portuguese version of PQRS
at dif ferent timepoint: baseline,15 minutes (T15), 40 minutes (T40), one and
three days af ter surgery. Full recovery defined as return to values identical or
higher than those measured at baseline, prior to surgery. Muscular strength
measured with KERN- MAP® Dynamometer. Ethics Committees approval was
obtained. Statistics used linear T-Test, Qui Square and Fisher exact test, data
presented as mean±SD for continuous variables. Interim analysis results presented
Results and Discussion: Thirty patients received neostigmine and 21 sugammadex.
Age and BMI 50.4±11.8 and 28.6±5.6 in the neostigmine group
and 38.2±12.7 and 24.7± 4.5 in the sugammadex group (p< 0,001). Overall
response rate at T15 was 86% for neostigmine and 95% for sugammadex (p=
0.22). Dif ferences in favor of sugammadex group noted in nociceptive and
emotional domains, 80 vs 100% respectively (p=0.04). Overall response rate
at T40 was 80% for neostigmine and 65% for sugammadex (p=0.33), primarily
reflecting constraints on activities of daily life. Muscular strength did not
dif fer. Improvements in recovery scores from T15 to T40 were observed in
both groups, without significant dif ferences . Postoperative assessments were
feasible using PQRS at T15 and T40 and seem appropriate for comparisons
between postoperative recovery domains and overall recovery . These preliminary
results suggest nociceptive and emotional domains recovery at T15
may be faster with sugammadex.
Conclusion: The results support the adopted PQRS validation process and
the potential of this scale as a tool for the evaluation of post operative recovery
evaluation in the Portuguese population
Description
Keywords
Citation
European Journal of Anaesthesiology: June 2013 - Volume 30 - Issue - p 14–14