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Cutaneous primary B-cell lymphomas: from diagnosis to treatment

dc.contributor.authorLima, M.
dc.date.accessioned2016-07-19T10:56:00Z
dc.date.available2016-07-19T10:56:00Z
dc.date.issued2015
dc.description.abstractPrimary cutaneous B-cell lymphomas are a heterogeneous group of mature B-cells neoplasms with tropism for the skin, whose biology and clinical course differ significantly from the equivalent nodal lymphomas. The most indolent forms comprise the primary cutaneous marginal zone and follicle center B-cell lymphomas that despite the excellent prognosis have cutaneous recurrences very commonly. The most aggressive forms include the primary cutaneous large B-cell lymphomas, consisting in two major groups: the leg type, with poor prognosis, and others, the latter representing a heterogeneous group of lymphomas from which specific entities are supposed to be individualized over time, such as intravascular large B-cell lymphomas. Treatment may include surgical excision, radiotherapy, antibiotics, corticosteroids, interferon, monoclonal antibodies and chemotherapy, depending on the type of lymphoma and on the type and location of the skin lesions. In subtypes with good prognosis is contraindicated overtreatment and in those associated with a worse prognosis the recommended therapy relies on CHOP-like regimens associated with rituximab, assisted or not with local radiotherapy. We review the primary cutaneous B-cell lymphomas, remembering the diagnostic criteria, differential diagnosis, classification, and prognostic factors and presenting the available therapies.pt_PT
dc.identifier.citationAn Bras Dermatol. 2015 Sep-Oct;90(5):687-706pt_PT
dc.identifier.doi10.1590/abd1806-4841.20153638pt_PT
dc.identifier.issn0365-0596
dc.identifier.urihttp://hdl.handle.net/10400.16/1960
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociedade Brasileira de Dermatologiapt_PT
dc.relation.publisherversionhttp://www.scielo.br/pdf/abd/v90n5/0365-0596-abd-90-05-0687.pdfpt_PT
dc.subjectAntineoplastic combined chemotherapy protocolspt_PT
dc.subjectFollicular lymphomapt_PT
dc.subjectInterferon-alphapt_PT
dc.subjectLymphomapt_PT
dc.subjectLymphoma, B-Cellpt_PT
dc.subjectMonoclonal antibodiespt_PT
dc.subjectRadiotherapypt_PT
dc.subjectPseudolymphomapt_PT
dc.subjectSkinpt_PT
dc.subjectSkin Neoplasmspt_PT
dc.titleCutaneous primary B-cell lymphomas: from diagnosis to treatmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceBrazilpt_PT
oaire.citation.endPage706pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage687pt_PT
oaire.citation.titleAnais Brasileiros de Dermatologiapt_PT
oaire.citation.volume90pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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