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Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence country

2014-12Journal article Open access
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dc.contributor.authorAreia, M.
dc.contributor.authorAlves, S.
dc.contributor.authorBrito, D.
dc.contributor.authorCadime, A.
dc.contributor.authorCarvalho, R.
dc.contributor.authorSaraiva, S.
dc.contributor.authorFerreira, S.
dc.contributor.authorMoleiro, J.
dc.contributor.authorPereira, A.
dc.contributor.authorCarrasquinho, J.
dc.contributor.authorLopes, L.
dc.contributor.authorRamada, J.
dc.contributor.authorMarcos-Pinto, R.
dc.contributor.authorPedroto, I.
dc.contributor.authorContente, L.
dc.contributor.authorEliseu, L.
dc.contributor.authorVieira, A.
dc.contributor.authorSampaio, M.
dc.contributor.authorSousa, H.
dc.contributor.authorAlmeida, N.
dc.contributor.authorGregório, C.
dc.contributor.authorPortela, F.
dc.contributor.authorSofia, C.
dc.contributor.authorBraga, V.
dc.contributor.authorBaginha, E.
dc.contributor.authorBana e Costa, T.
dc.contributor.authorChagas, C.
dc.contributor.authorMendes, L.
dc.contributor.authorMagalhães-Costa, P.
dc.contributor.authorMatos, L.
dc.contributor.authorGonçalves, F.
dc.contributor.authorDinis-Ribeiro, M.
dc.date.accessioned2015-10-12T11:40:57Z
dc.date.available2015-10-12T11:40:57Z
dc.date.issued2014-12
dc.description.abstractBACKGROUND AND AIMS: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. METHODS: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. RESULTS: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). CONCLUSION: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis.pt_PT
dc.identifier.citationJ Gastrointestin Liver Dis, December 2014 Vol. 23(4): 371-378pt_PT
dc.identifier.doihttp://dx.doi.org/10.15403/jgld.2014.1121.234.hrq
dc.identifier.urihttp://hdl.handle.net/10400.16/1858
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMedical University Press Cluj, Romaniapt_PT
dc.relation.publisherversionhttp://dx.doi.org/10.15403/jgld.2014.1121.234.hrqpt_PT
dc.subjectGastrointestinal endoscopypt_PT
dc.subjectQoLpt_PT
dc.subjectgastric cancerpt_PT
dc.subjectintestinal metaplasiapt_PT
dc.subjectatrophic gastritispt_PT
dc.titleHealth-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence countrypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceRomaniapt_PT
oaire.citation.endPage378pt_PT
oaire.citation.startPage371pt_PT
oaire.citation.titleJournal of Gastrointestinal and Liver Diseasespt_PT
oaire.citation.volume23(4)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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