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EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survival

2014Journal article Open access
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dc.contributor.authorMonteiro, L.
dc.contributor.authorDelgado, M.
dc.contributor.authorRicardo, S.
dc.contributor.authorGarcez, F.
dc.contributor.authorBarbas-Amaral, J.
dc.contributor.authorPacheco, J.
dc.contributor.authorLopes, C.
dc.contributor.authorBousbaa, H.
dc.date.accessioned2015-07-20T10:57:39Z
dc.date.available2015-07-20T10:57:39Z
dc.date.issued2014
dc.description.abstractThe aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC. We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors (P = 0.002). Overexpression of EMMPRIN was correlated with high Ki-67 expression (P = 0.004). In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS) (P = 0.034). Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.por
dc.identifier.citationBiomed Res Int. 2014;2014:905680por
dc.identifier.doihttp://dx.doi.org/10.1155/2014/905680
dc.identifier.issn2314-6141
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10400.16/1823
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherHindawi Pub. Co.por
dc.relation.publisherversionhttp://dx.doi.org/10.1155/2014/905680por
dc.titleEMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survivalpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapor
oaire.citation.titleBioMed Research Internationalpor
oaire.citation.volume2014por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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