Publication
Bilirubin is independently associated with oxidized LDL levels in young obese patients
| dc.contributor.author | Nascimento, H. | |
| dc.contributor.author | Alves, A. | |
| dc.contributor.author | Coimbra, S. | |
| dc.contributor.author | Catarino, C. | |
| dc.contributor.author | Gomes, D. | |
| dc.contributor.author | Bronze-da-Rocha, E. | |
| dc.contributor.author | Costa, E. | |
| dc.contributor.author | Rocha-Pereira, P. | |
| dc.contributor.author | Aires, L. | |
| dc.contributor.author | Mota, J. | |
| dc.contributor.author | Mansilha, H. | |
| dc.contributor.author | Rêgo, C. | |
| dc.contributor.author | Santos-Silva, A. | |
| dc.contributor.author | Belo, L. | |
| dc.date.accessioned | 2016-07-26T11:46:52Z | |
| dc.date.available | 2016-07-26T11:46:52Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | BACKGROUND: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. FINDINGS: 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (β = 0.665, P < 0.001), followed by TB (β = -0.202, P = 0.002) and HOMAIR (β = 0.163, P = 0.010). CONCLUSIONS: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk. | pt_PT |
| dc.identifier.citation | Diabetol Metab Syndr. 2015 Jan 23;7:4 | pt_PT |
| dc.identifier.doi | 10.1186/1758-5996-7-4 | pt_PT |
| dc.identifier.issn | 1758-5996 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/1971 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | BioMed Central | pt_PT |
| dc.relation.publisherversion | http://dmsjournal.biomedcentral.com/articles/10.1186/1758-5996-7-4 | pt_PT |
| dc.subject | Bilirubin | pt_PT |
| dc.subject | Oxidized-LDL | pt_PT |
| dc.subject | Oxidative stress | pt_PT |
| dc.subject | Atherosclerosis | pt_PT |
| dc.subject | Pediatric obesity | pt_PT |
| dc.title | Bilirubin is independently associated with oxidized LDL levels in young obese patients | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FDTP-DES%2F0393%2F2012/PT | |
| oaire.citation.conferencePlace | England | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 4 | pt_PT |
| oaire.citation.title | Diabetology and Metabolic Syndrome | pt_PT |
| oaire.citation.volume | 7 | pt_PT |
| oaire.fundingStream | 5876-PPCDTI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | eb01db3b-539f-41d0-9dc3-f43c97a2e5d6 | |
| relation.isProjectOfPublication.latestForDiscovery | eb01db3b-539f-41d0-9dc3-f43c97a2e5d6 |