Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn's Disease Patient

Alves da Silva, Joana Inês; Caetano, Cidalina; Pedroto, Isabel

http://hdl.handle.net/10400.16/2456

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Authors

Alves da Silva, Joana Inês

Caetano, Cidalina

Pedroto, Isabel

Abstract(s)

Introduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of patients. Case presentation: We report the case of a Crohn's disease patient who developed sialadenitis as an AE to AZA. Discussion and conclusion: To our knowledge this AE has been reported only once in the literature. Sialadenitis is a common disorder and refers to inflammation of a salivary gland. It has many causes, such as bacterial and viral infections, ductal obstruction, and drugs. There are several AEs related to this drug, categorized as dose-dependent and dose-independent. Their knowledge is essential for therapeutic management in IBD, which is already challenging, requiring an individualized approach.

Keywords

Azathioprine Adverse effect Sialadenitis Crohn’s disease

URI

http://hdl.handle.net/10400.16/2456

Citation

Alves da Silva JI, Caetano C, Pedroto I. Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn's Disease Patient. GE Port J Gastroenterol. 2020 Aug;27(5):361-363. doi: 10.1159/000505037. Epub 2020 Jan 7. PMID: 32999909; PMCID: PMC7506223.