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Hepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysis

dc.contributor.authorBernardo, A.
dc.contributor.authorOliveira, J.
dc.contributor.authorSantos, O.
dc.contributor.authorCarvalho, M.
dc.contributor.authorCabrita, A.
dc.contributor.authorRodrigues, A.
dc.date.accessioned2015-07-21T11:23:17Z
dc.date.available2015-07-21T11:23:17Z
dc.date.issued2014
dc.description.abstractBACKGROUND: Hepatocyte growth factor (HGF) counteracts peritoneal fibrosis in animal models and in-vitro studies, but no study explored effluent HGF in peritoneal dialysis (PD) patients with ultrafiltration failure (UFF). Our aim was to assess the relationship between effluent HGF with UF profile, free water transport (FWT) and small-solute transport. METHODS: We performed 4-hour, 3.86% PET with additional UF measurement at 60 minutes in 68 PD patients. MTACcreatinine, FWT, small-pore ultrafiltration, and effluent HGF were quantified. RESULTS: Effluent HGF negatively correlated with UF (r=-0.80, p=0.009) and FWT (r=-0.69, p=0.04). Patients with UFF had higher dialysate HGF (103 pg/mL vs 77 pg/mL, p=0.018) and, although not statistically significant, those with FWT compromise had also higher dialysate HGF compared with subgroup of UFF without FWT compromise (104 pg/mL vs 88 pg/mL, p=0.08). FWT≤45% without clinical UFF was documented in some patients who also had increased effluent HGF. CONCLUSIONS: Dialysate HGF concentration is significantly higher among patients with UFF, specially, if FWT is impaired, being a sign of peritoneal membrane deterioration.por
dc.description.sponsorshipThis study was partially performed with the help of investigations grants from Sociedade Portuguesa de Nefrologia. This work was also supported by UMIB/ICBAS – University of Porto (UP). Multidisciplinary Unit for Biomedical Research (UMIB) is funded by grants from Foundation for Science and Technology (Fcomp-01-0124-FEDER-015896)por
dc.identifier.citationBMC Nephrol. 2014;15:201por
dc.identifier.doi10.1186/1471-2369-15-201
dc.identifier.issn1471-2369
dc.identifier.urihttp://hdl.handle.net/10400.16/1827
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBioMed Centralpor
dc.relation.publisherversionhttp://www.biomedcentral.com/1471-2369/15/201por
dc.subjectHepatocyte growth factorpor
dc.subjectPeritoneal membranepor
dc.subjectUltrafiltration failurepor
dc.subjectWater transportpor
dc.titleHepatocyte growth factor signalizes peritoneal membrane failure in peritoneal dialysispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpor
oaire.citation.titleBMC nephrologypor
oaire.citation.volume15por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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