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Publication
Enzymatic vitreolysis for the treatment of tractional diabetic macular edema
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Advisor(s)
Abstract(s)
Background: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer anti-vascular endothelial growth factor injections.
Objectives: The aim of this study was to demonstrate that diabetic macular edema can be improved by inducing the release of a vitreomacular adhesion, with less than 2500 μm, with enzymatic vitreolysis.
Methods: From a retrospective analysis of clinical records from patients with diabetic retinopathy, patients with diabetic macular edema and vitreomacular adhesion <2500 μm were selected for a single-arm prospective study. The primary endpoint was to control diabetic macular edema with fewer anti-vascular endothelial growth factor injections after an observed vitreomacular adhesion release. A statistical subanalysis was performed for the following two groups: the group with vitreomacular adhesion release (group 1) and the group without vitreomacular adhesion release (group 2).
Results: A total of 23 eyes from 19 patients were included. A reduction of the median number of injections was achieved in group 1 (p = 0.006). Adverse events were mild and transitory.
Conclusion: Release of vitreomacular adhesion <2500 μm through enzymatic vitreolysis contributed to the control and stabilization of diabetic macular edema with fewer anti-vascular endothelial growth factor injections, reducing the burden and the risks related to these invasive and frequently chronic treatments.
Description
Keywords
anti-vascular endothelial growth factor injections diabetic macular edema ocriplasmin vitreolysis vitreomacular traction
Citation
Pessoa B, Coelho J, Coelho C, et al. Enzymatic vitreolysis for the treatment of tractional diabetic macular edema. Ther Adv Ophthalmol. 2019;11:2515841419869511. Published 2019 Aug 22. doi:10.1177/2515841419869511
Publisher
SAGE Publications