Repository logo
 
Publication

Enzymatic vitreolysis for the treatment of tractional diabetic macular edema

2019Journal article Open access
Simple item page
dc.contributor.authorPessoa, Bernardete
dc.contributor.authorCoelho, João
dc.contributor.authorCoelho, Constança
dc.contributor.authorMonteiro, Sílvia
dc.contributor.authorAbreu, Carolina
dc.contributor.authorFigueira, João
dc.contributor.authorMeireles, Angelina
dc.contributor.authorBeirão, João
dc.date.accessioned2020-08-27T10:09:17Z
dc.date.available2020-08-27T10:09:17Z
dc.date.issued2019
dc.description.abstractBackground: A new approach to address focal vitreomacular adhesion in patients with diabetic macular edema may control and stabilize diabetic macular edema with fewer anti-vascular endothelial growth factor injections. Objectives: The aim of this study was to demonstrate that diabetic macular edema can be improved by inducing the release of a vitreomacular adhesion, with less than 2500 μm, with enzymatic vitreolysis. Methods: From a retrospective analysis of clinical records from patients with diabetic retinopathy, patients with diabetic macular edema and vitreomacular adhesion <2500 μm were selected for a single-arm prospective study. The primary endpoint was to control diabetic macular edema with fewer anti-vascular endothelial growth factor injections after an observed vitreomacular adhesion release. A statistical subanalysis was performed for the following two groups: the group with vitreomacular adhesion release (group 1) and the group without vitreomacular adhesion release (group 2). Results: A total of 23 eyes from 19 patients were included. A reduction of the median number of injections was achieved in group 1 (p = 0.006). Adverse events were mild and transitory. Conclusion: Release of vitreomacular adhesion <2500 μm through enzymatic vitreolysis contributed to the control and stabilization of diabetic macular edema with fewer anti-vascular endothelial growth factor injections, reducing the burden and the risks related to these invasive and frequently chronic treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPessoa B, Coelho J, Coelho C, et al. Enzymatic vitreolysis for the treatment of tractional diabetic macular edema. Ther Adv Ophthalmol. 2019;11:2515841419869511. Published 2019 Aug 22. doi:10.1177/2515841419869511pt_PT
dc.identifier.doi10.1177/2515841419869511pt_PT
dc.identifier.issn2515-8414
dc.identifier.urihttp://hdl.handle.net/10400.16/2448
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/2515841419869511?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200www.ncbi.nlm.nih.govpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectanti-vascular endothelial growth factor injectionspt_PT
dc.subjectdiabetic macular edemapt_PT
dc.subjectocriplasminpt_PT
dc.subjectvitreolysispt_PT
dc.subjectvitreomacular tractionpt_PT
dc.titleEnzymatic vitreolysis for the treatment of tractional diabetic macular edemapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.startPage2515841419869511pt_PT
oaire.citation.titleTherapeutic advances in ophthalmologypt_PT
oaire.citation.volume11pt_PT
person.familyNamePessoa
person.familyNameCoelho
person.familyNameCoelho
person.familyNameMeireles
person.familyNameBeirão
person.givenNameBernardete
person.givenNameJoão
person.givenNameConstança
person.givenNameAngelina
person.givenNameJoão Nuno Melo
person.identifier.ciencia-id0E1B-7EB2-B90F
person.identifier.ciencia-id7515-8385-064B
person.identifier.ciencia-id0214-5233-EE9D
person.identifier.orcid0000-0002-5673-1561
person.identifier.orcid0000-0003-2261-5682
person.identifier.orcid0000-0002-5331-2257
person.identifier.orcid0000-0001-9148-2786
person.identifier.orcid0000-0001-8642-7010
person.identifier.scopus-author-id7005608345
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfa0e3b13-5da3-4f74-a184-22358fc19d38
relation.isAuthorOfPublication9d2244b9-b054-46ab-8d35-d0a369849715
relation.isAuthorOfPublication7c266ee8-376a-40c3-acbf-81aacf28197f
relation.isAuthorOfPublication8832627a-5103-43bb-a479-6556c8b18d44
relation.isAuthorOfPublication03b98348-ce82-4043-bb58-db089fcc21d6
relation.isAuthorOfPublication.latestForDiscoveryfa0e3b13-5da3-4f74-a184-22358fc19d38

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Enzymatic vitreolysis for the treatment of tractional diabetic macular edema.pdf
Size:
561.58 KB
Format:
Adobe Portable Document Format
Download

Collections

SOFT - Artigos publicados em revistas indexadas na Pubmed/Medline