Repository logo
 
Publication

Chemokine Receptor Expression on Normal Blood CD56(+) NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population

dc.contributor.authorLima, M.
dc.contributor.authorLeander, M.
dc.contributor.authorSantos, M.
dc.contributor.authorSantos, A.
dc.contributor.authorLau, C.
dc.contributor.authorQueirós, M.
dc.contributor.authorGonçalves, M.
dc.contributor.authorFonseca, S.
dc.contributor.authorMoura, J.
dc.contributor.authorTeixeira, M.
dc.contributor.authorOrfao, A.
dc.date.accessioned2016-07-19T11:51:50Z
dc.date.available2016-07-19T11:51:50Z
dc.date.issued2015
dc.description.abstractStudies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. We report on the expression of the inflammatory and homeostatic CKR on normal blood CD56(+low) CD16(+) and CD56(+high)  CD16(-/+low) NK-cells. Conventional CD56(+low) and CD56(+high) NK-cells present in the normal PB do express CKR for inflammatory cytokines, although with different patterns CD56(+low) NK-cells are mainly CXCR1/CXCR2(+) and CXCR3/CCR5(-/+), whereas mostly CD56(+high) NK-cells are CXCR1/CXCR2(-) and CXCR3/CCR5(+). Both NK-cell subsets have variable CXCR4 expression and are CCR4(-) and CCR6(-). The CKR repertoire of the CD56(+low) NK-cells approaches to that of neutrophils, whereas the CKR repertoire of the CD56(+high) NK-cells mimics that of Th1(+) T cells, suggesting that these cells are prepared to migrate into inflamed tissues at different phases of the immune response. In addition, we describe a subpopulation of NK-cells with intermediate levels of CD56 expression, which we named CD56(+int) NK-cells. These NK-cells are CXCR3/CCR5(+), they have intermediate levels of expression of CD16, CD62L, CD94, and CD122, and they are CD57(-) and CD158a(-). In view of their phenotypic features, we hypothesize that they correspond to a transitional stage, between the well-known CD56(+high) and CD56(+low) NK-cells populations.pt_PT
dc.description.sponsorshipThis work has been partially supported by a grant of the “Associação Portuguesa Contra a Leucemia” for the project “caracterização imunofenotípica de leucemias e linfomas de células T e NK: padrão de expressão de receptores de quimiocinas como determinantes do tropismo tecidular da célula neoplásica e do comportamento clínico-biológico da doença” and by the “Forum Hematológico do Norte,” Portugalpt_PT
dc.identifier.citationJ Immunol Res. 2015;2015:839684pt_PT
dc.identifier.doi10.1155/2015/839684pt_PT
dc.identifier.issn2314-7156
dc.identifier.urihttp://hdl.handle.net/10400.16/1961
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttp://www.hindawi.com/journals/jir/2015/839684/pt_PT
dc.titleChemokine Receptor Expression on Normal Blood CD56(+) NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEgyptpt_PT
oaire.citation.endPage18pt_PT
oaire.citation.startPage839684pt_PT
oaire.citation.titleJournal of Immunology Researchpt_PT
oaire.citation.volume2015pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Chemokine Receptor Expression.pdf
Size:
2.81 MB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.35 KB
Format:
Item-specific license agreed upon to submission
Description: