Publication
Intraclonal diversity in a Sezary syndrome with a differential response to 2âdeoxycoformycin of the two lymphoma cell populations
| dc.contributor.author | GRANJO, E. | |
| dc.contributor.author | LIMA, M. | |
| dc.contributor.author | LOPES, J.M. | |
| dc.contributor.author | CUNHA, N. | |
| dc.contributor.author | TEIXEIRA, M. A. | |
| dc.contributor.author | SANTOS, F. | |
| dc.contributor.author | CANDEIAS, J. | |
| dc.contributor.author | RESENDE, C. | |
| dc.contributor.author | SANTOS, A.H. | |
| dc.contributor.author | BALANZATEGUI, A. | |
| dc.contributor.author | ORFAO, A. | |
| dc.contributor.author | MATUTES, E. | |
| dc.date.accessioned | 2011-01-19T10:49:30Z | |
| dc.date.available | 2011-01-19T10:49:30Z | |
| dc.date.issued | 2002-12 | |
| dc.description.abstract | Br J Haematol. 2002 Dec;119(3):629-33. Intraclonal diversity in a Sezary syndrome with a differential response to 2-deoxycoformycin of the two lymphoma cell populations. Granjo E, Lima M, Lopes JM, Cunha N, Teixeira Mdos A, Santos F, Candeias J, Resende C, Santos AH, Balanzategui A, OrfĂŁo A, Matutes E. Department of Clinical Haematology, Hospital Geral de SĂŁo JoĂŁo, Porto, Portugal. npp46740@mail.telpac.pt Abstract We report a case of Sezary syndrome with two abnormal CD4+ T-cell populations detected in the peripheral blood by flow cytometry immunophenotyping and DNA cell content, suggesting a biclonal T-cell lymphoproliferative disorder. Despite these findings, molecular analysis of the T-cell receptor genes was consistent with a monoclonal T-cell proliferation, supporting the existence of intraclonal diversity rather than a true biclonal disease. The patient achieved a transient response with 2-deoxycoformycin, with a selective decrease of the larger/hyperploid T-cell population; later on, an increased representation of this T-cell population was observed concomitantly with clinical relapse. PMID: 12437636 [PubMed - indexed for MEDLINE] | por |
| dc.identifier.issn | (ISSN: 0007-1048) | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/516 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Wiley-Blackwell | por |
| dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2002.03889.x/pdf | por |
| dc.title | Intraclonal diversity in a Sezary syndrome with a differential response to 2âdeoxycoformycin of the two lymphoma cell populations | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | London | por |
| oaire.citation.title | British Journal of Haematology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |