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Body fat percentage is a major determinant of total bilirubin independently of UGT1A1*28 polymorphism in young obese

dc.contributor.authorBelo, L.
dc.contributor.authorNascimento, H.
dc.contributor.authorKohlova, M.
dc.contributor.authorBronze-da-Rocha, E.
dc.contributor.authorFernandes, J.
dc.contributor.authorCosta, E.
dc.contributor.authorCatarino, C.
dc.contributor.authorAires, L.
dc.contributor.authorMansilha, H.
dc.contributor.authorRocha-Pereira, P.
dc.contributor.authorQuintanilha, A.
dc.contributor.authorRêgo, C.
dc.contributor.authorSantos-Silva, A.
dc.date.accessioned2015-10-27T11:31:55Z
dc.date.available2015-10-27T11:31:55Z
dc.date.issued2014
dc.description.abstractOBJECTIVES: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals. METHODS: 350 obese (mean age of 11.6 years; 52% females) and 79 controls (mean age of 10.5 years; 59% females) were included. Total bilirubin and C-reactive protein (CRP) plasma levels, hemogram, anthropometric data and UGT1A1 polymorphism were determined. In a subgroup of 74 obese and 40 controls body composition was analyzed by dual-energy X-ray absorptiometry. RESULTS: The UGT1A1 genotype frequencies were 49.9%, 42.7% and 7.5% for 6/6, 6/7 and 7/7 genotypes, respectively. Patients with 7/7 genotype presented the highest total bilirubin levels, followed by 6/7 and 6/6 genotypes. Compared to controls, obese patients presented higher erythrocyte count, hematocrit, hemoglobin and CRP levels, but no differences in bilirubin or in UGT1A1 genotype distribution. Body fat percentage was inversely correlated with bilirubin in obese patients but not in controls. This inverse association was observed either in 6/7 or 6/6 genotype obese patients. UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis). CONCLUSION: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels. Obese individuals with 6/6 UGT1A1 genotype and higher body fat mass may benefit from a closer clinical follow-up.pt_PT
dc.description.sponsorshipThis work was funded by FEDER funds through the Operational Competitiveness Programme – COMPETE and by National Funds through FCT – Fundação para a Ciência e a Tecnologia under the project FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012). A PhD grant was attributed to H. Nascimento by FCT (SFRH/BD/48060/2008). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.identifier10.1371/journal.pone.0098467
dc.identifier.citationPLoS One. 2014;9(6):e98467pt_PT
dc.identifier.doi10.1371/journal.pone.0098467
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.16/1871
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPublic Library of Sciencept_PT
dc.relationSFRH/BD/48060/2008pt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098467pt_PT
dc.titleBody fat percentage is a major determinant of total bilirubin independently of UGT1A1*28 polymorphism in young obesept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FDTP-DES%2F0393%2F2012/PT
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.titlePloS onept_PT
oaire.citation.volume9(6)pt_PT
oaire.fundingStream5876-PPCDTI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationeb01db3b-539f-41d0-9dc3-f43c97a2e5d6
relation.isProjectOfPublication.latestForDiscoveryeb01db3b-539f-41d0-9dc3-f43c97a2e5d6

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