Publication
The DOse REsponse Multicentre International Collaborative Initiative (DO‐RE‐MI)
| dc.contributor.author | MONTI, G. | |
| dc.contributor.author | HERRERA, M. | |
| dc.contributor.author | KINDGEN‐MILLES, D. | |
| dc.contributor.author | MARINHO, A. | |
| dc.contributor.author | CRUZ, D. | |
| dc.contributor.author | MARIANO, F. | |
| dc.contributor.author | GIGLIOLA, G. | |
| dc.contributor.author | MORETTI, E. | |
| dc.contributor.author | ALESSANDRI, E. | |
| dc.contributor.author | ROBERT, R. | |
| dc.contributor.author | RONCO, C. | |
| dc.contributor.author | DOSE RESPONSE MULTICENTRE INTERNATIONAL COLLABORATIVE INITIATIVE SCIENTIFIC COMMITTEE | |
| dc.date.accessioned | 2011-03-16T11:27:43Z | |
| dc.date.available | 2011-03-16T11:27:43Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | Contrib Nephrol. 2007;156:434-43. The DOse REsponse Multicentre International Collaborative Initiative (DO-RE-MI). Monti G, Herrera M, Kindgen-Milles D, Marinho A, Cruz D, Mariano F, Gigliola G, Moretti E, Alessandri E, Robert R, Ronco C; Dose Response Multicentre International Collaborative Initiative Scientific Committee. Department of Anesthesiology and Intensive Care, Hospital Niguarda, Milan, Italy, and Anesthesiology Clinic, University of Düsseldorf, Germany. Gianpaola.monti@ospedaleniguarda.it Abstract BACKGROUND: Current practices for renal replacement therapy (RRT) in ICU remain poorly defined. The observational DOse REsponse Multicentre International collaborative initiative (DO-RE-MI) survey addresses the issue of how the different modes of RRT are currently chosen and performed. The primary endpoint of DO-RE-MI will be the delivered dose versus in ICU, 28-day, and hospital mortality, and the secondary endpoint, the hemodynamic response to RRT. Here, we report the first preliminary descriptive analysis after 1-year recruitment. METHODS: Data from 431 patients in need of RRT with or without acute renal failure (mean age 61.2+15.9) from 25 centers in 5 countries (Spain, Italy, Germany, Portugal, France) were entered in electronic case report forms (CRFs) available via the website acutevision.net. RESULTS: On admission, 51% patients came from surgery, 36% from the emergency department, and 16% from internal medicine. On admission, mean SOFA and SAPS II were 13 and 50, respectively. The first criteria to initiate RRT was the RIFLE in 38% (failure: 70%, injury: 25%, risk: 22%), the second the high urea/creatinine, and the third immunomodulation. A total of 3,010 cumulative CRF were reported: continuous venovenous hemodiafiltration (CVVHDF) 60%, continuous venovenous hemofiltration (CVVH) 15%, intermittent hemodialysis (IHD) 15%, high-volume hemofiltration (HVHF) 7%, continuous venovenous hemodialysis (CVVHD) 1%, and coupled plasma filtration adsorption/CVVD 2%. In 15% of cases, the patient was shifted to another modality. Mean blood flow rates (ml/min) in the different modalities were: 145 (CVVHDF), 200 (CVVH), 215 (IHD), 283 (HVHF), and 150 (CVVHD). Downtime ranged from 8 to 28% of the total treatment time. Clotting of the circuit accounted for 74% of treatment interruptions. CONCLUSIONS: Despite a large variability in the criteria of choice of RRT, CVVHDF remains the most used (49%). Clotting and clinical reasons were the most common causes for RRT downtime. In continuous RRT, a large variability in the delivered dose is observed in the majority of patients and often in the same patient from one day to another. Preliminary analysis suggests that in a large number of cases the delivered dose is far from the 'adequate' 35 ml/h/kg. | por |
| dc.identifier.issn | 0302-5144 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/558 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Krager | por |
| dc.relation.publisherversion | http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowFreePage&ArtikelNr=0000102137&Ausgabe=0&ProduktNr=233035&filefp=0000102137fp.pdf | por |
| dc.title | The DOse REsponse Multicentre International Collaborative Initiative (DO‐RE‐MI) | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Contributions to Nephrology | por |
| rcaap.rights | restrictedAccess | por |
| rcaap.type | article | por |