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Nasal Polyposis and Serum Albumin: Systemic Effects of Local Inflammation

2023-02Journal article Open access
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dc.contributor.authorSousa-Machado, André
dc.contributor.authorRosa, Francisco
dc.contributor.authorSilva, Ana
dc.contributor.authorMeireles, Luis
dc.date.accessioned2024-06-18T08:55:47Z
dc.date.available2024-06-18T08:55:47Z
dc.date.issued2023-02
dc.description.abstractIntroduction The genesis of chronic rhinosinusitis is always a topic of debate. A polyp is a pale, edematous tissue emerging mostly from the middle meatus. An epithelial injury caused by continuous inflammation of the nasal mucosa is considered to be a possible cause of the genesis of nasosinusal polyps. Objective To understand the link between serum albumin levels and nasal polyposis. Methods A retrospective study of 180 consecutive patients between January 2016 and January 2020 at our center. We then divided the patients into three age- and gender-matched groups: 60 patients with chronic rhinosinusitis with nasal polyposis, 60 patients with chronic rhinosinusitis without nasal polyposis, and a control group with 60 patients. No patient had a history of any pathology that could alter serum albumin. We then compared the level of serum albumin between the three groups. Results The group of patients with rhinosinusitis and nasal polyposis consisted of 60 patients with a serum albumin value of 4.49 ± 0.29 g/dL, whereas in the control group, the serum albumin value was 4.67 ± 0.2 g/dL. We found a significant difference between the group with nasal polyposis and the other two groups evaluated: chronic rhinosinusitis without nasal polyposis (p<0.001) and the control group (p<0.001). Conclusions Lower levels of serum albumin can be seen in patients with chronic rhinosinusitis with nasal polyposis. Further studies should aim to apply its value since it is a non-expensive marker, to the follow-up of those patients or even to stratify them according to their endotype.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDe Sousa Machado A, Rosa F, Silva A, Meireles L. Nasal Polyposis and Serum Albumin: Systemic Effects of Local Inflammation. Cureus. 2023;15(2):e34859. doi:10.7759/cureus.34859pt_PT
dc.identifier.doi10.7759/cureus.34859pt_PT
dc.identifier.issn2168-8184
dc.identifier.urihttp://hdl.handle.net/10400.16/2945
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCureus, Inc.pt_PT
dc.relation.publisherversionhttps://www.cureus.com/articles/95339-nasal-polyposis-and-serum-albumin-systemic-effects-of-local-inflammation#!/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectalbuminpt_PT
dc.subjectchronicpt_PT
dc.subjectinflammationpt_PT
dc.subjectlocal inflammationpt_PT
dc.subjectnasalpt_PT
dc.subjectnasal polyposispt_PT
dc.subjectnasal polypspt_PT
dc.subjectnosept_PT
dc.subjectserum albuminpt_PT
dc.subjectsinusitispt_PT
dc.titleNasal Polyposis and Serum Albumin: Systemic Effects of Local Inflammationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceUnited States of Americapt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPagee34859pt_PT
oaire.citation.titleCureuspt_PT
oaire.citation.volume15pt_PT
person.familyNameSousa-Machado
person.givenNameAndré
person.identifier.orcid0000-0002-8877-8014
person.identifier.ridHIR-6257-2022
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc0f5906f-a70f-4f92-81af-842a6e8e46db
relation.isAuthorOfPublication.latestForDiscoveryc0f5906f-a70f-4f92-81af-842a6e8e46db

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