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BDNF and CGRP interaction: implications in migraine susceptibility

dc.contributor.authorLemos, C.
dc.contributor.authorMendonça, D.
dc.contributor.authorPereira-Monteiro, J.
dc.contributor.authorBarros, J.
dc.contributor.authorSequeiros, J.
dc.contributor.authorAlonso, I.
dc.contributor.authorSousa, A.
dc.date.accessioned2011-07-11T16:15:12Z
dc.date.available2011-07-11T16:15:12Z
dc.date.issued2010-11
dc.description.abstractAbstract OBJECTIVES: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. METHODS: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP-rs1553005-of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis. RESULTS: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio=1.88, 95% confidence interval: 1.20-2.93) for migraineurs. CONCLUSION: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored.por
dc.identifier.citationCephalalgia. 2010 Nov;30(11):1375-82por
dc.identifier.issn0333-1024
dc.identifier.urihttp://hdl.handle.net/10400.16/739
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSAGE Publicationspor
dc.titleBDNF and CGRP interaction: implications in migraine susceptibilitypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1382por
oaire.citation.issue30(11)por
oaire.citation.startPage1375por
oaire.citation.titleCephalalgiapor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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