Publication
BDNF and CGRP interaction: implications in migraine susceptibility
| dc.contributor.author | Lemos, C. | |
| dc.contributor.author | Mendonça, D. | |
| dc.contributor.author | Pereira-Monteiro, J. | |
| dc.contributor.author | Barros, J. | |
| dc.contributor.author | Sequeiros, J. | |
| dc.contributor.author | Alonso, I. | |
| dc.contributor.author | Sousa, A. | |
| dc.date.accessioned | 2011-07-11T16:15:12Z | |
| dc.date.available | 2011-07-11T16:15:12Z | |
| dc.date.issued | 2010-11 | |
| dc.description.abstract | Abstract OBJECTIVES: Migraine pathophysiology involves several pathways. Our aims were to explore a possible role of the brain-derived neurotrophic factor gene (BDNF) in migraine susceptibility; to study, for the first time, the calcitonin gene-related peptide gene (CGRP); and a possible interaction between the two. METHODS: Using a case-control approach, four tagging single nucleotide polymorphisms (SNPs) (rs7124442, rs6265, rs11030107, and rs2049046) of BDNF and one tagging SNP-rs1553005-of CGRP were analyzed in 188 cases and 287 controls. A multivariable logistic regression was performed, adjusting for gender. Allelic and haplotypic frequencies were estimated. Interaction was assessed by a stepwise multivariable-logistic regression and confirmed by a multifactor dimensionality reduction analysis. RESULTS: No significant main effects were found; however, a significant interaction was found between BDNF and CGRP, showing an increased risk for the AT-genotype of rs2049046 and the GC-genotype of rs1553005 (odds ratio=1.88, 95% confidence interval: 1.20-2.93) for migraineurs. CONCLUSION: Our data support the hypothesis of an interaction between BDNF and CGRP in migraine susceptibility that should be further explored. | por |
| dc.identifier.citation | Cephalalgia. 2010 Nov;30(11):1375-82 | por |
| dc.identifier.issn | 0333-1024 | |
| dc.identifier.uri | http://hdl.handle.net/10400.16/739 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | SAGE Publications | por |
| dc.title | BDNF and CGRP interaction: implications in migraine susceptibility | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1382 | por |
| oaire.citation.issue | 30(11) | por |
| oaire.citation.startPage | 1375 | por |
| oaire.citation.title | Cephalalgia | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
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