Browsing by Author "Alves, A."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- Bilirubin is independently associated with oxidized LDL levels in young obese patientsPublication . Nascimento, H.; Alves, A.; Coimbra, S.; Catarino, C.; Gomes, D.; Bronze-da-Rocha, E.; Costa, E.; Rocha-Pereira, P.; Aires, L.; Mota, J.; Mansilha, H.; Rêgo, C.; Santos-Silva, A.; Belo, L.BACKGROUND: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. FINDINGS: 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (β = 0.665, P < 0.001), followed by TB (β = -0.202, P = 0.002) and HOMAIR (β = 0.163, P = 0.010). CONCLUSIONS: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk.
- Pseudo-quisto abdominalPublication . Sousa, M.; Costa, J.; Alves, A.; Salgado, M.Apresentamos o caso clínico de uma criança de 5 anos de idade, sexo masculino, com hidrocefalia secundária a quisto porencefálico congénito, com sistema de derivação ventriculo-peritoneal (DVP) do LCR desde os 12 meses de idade, que se complicou, 4 anos depois, de pseudo-quisto abdominal (PQA), em cuja cultura do conteúdo se desenvolveu uma Brucella spp. A revisão da literatura sobre peritonite/ ascite por Brucella, mostrou tratarem- se de situações muito raras, ocorrendo mais em adultos com doença grave subjacente ou em indivíduos com catéter intra-abdominal com sistemas de DVP. Na literatura internacional estão publicados cerca de 20 casos clínicos de ascite / peritonite por Brucella. Contudo não encontrámos nenhuma outra descrição de infecção dum PQA por Brucella. ABSTRACT We present a case of a five year-old boy with hydrocephaly secondary to a congenital porencephalic cyst, with ventricular-peritoneal shunt of cerebral-spinal fluid, since the age of 12 months. He developed, 4 years later, an abdominal pseudo-cyst. The culture of the pseudo-cyst’s content was positive for Brucella spp. The review of literature shows that peritonitis / ascitis caused by Brucella, is rare, and takes place in serious ill adults or in individuals with intra-abdominal catheter of ventricular-peritoneal shunt. The authors found 20 cases of peritonitis / ascitis caused by Brucella, in the international literature, however, we have not found any description of an abdominal pseudo-cyst infection by this bacteria.