Browsing by Author "Monteiro, M."
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- [Can we find predictive factors of postoperative vomiting after day surgery?]Publication . Lemos, P.; Monteiro, M.; Fonseca, L.; Regalado, A.Abstract A retrospective analyses of patients submitted to surgery on a day basis was made through our database. The goal of the study was to identify risk factors of postoperative vomiting associated to day surgery. 2115 patients operated between January 2003 and November 2004 on our day surgery unit were included. 70 patients (3,3%) suffered at least on episode of postoperative vomiting. Several factors were analysed: age, sex, surgical speciality, ASA physical status, anaesthetic technique and the duration of anesthesia. Chi-Square Test was used for testing each factor individually. Differences were considered significant when p <0,05. Logistic regression was then used to identify the multivariate association strength of these factors. The female sex (Odds ratio =4,94) and the duration of anesthesia when longer than 180 minutes (Odds ratio =8,13), had been associated to a higher incidence of postoperative vomiting, while loco-regional technique (Odds ratio = 0,15) and sedation with local anaesthesia (Odds ratio =0,09) had been associated with a lower incidence. Authors evidence the importance of the identification of postoperative vomiting risk factors that will allow us to establish better guidelines on postoperative nausea and vomiting prophylaxis in these patients and to improve the quality of our clinical care and the satisfaction of our patients. Através da análise do registo informatizado de dados dos doentes operados em regime de ambulatório, os autores procuraram identificar factores de risco que se encontrassem associados a uma maior incidência de vómitos no pós-operatório (VPO). Incluíram-se 2115 doentes submetidos a cirurgia entre Janeiro de 2003 e Novembro de 2004, tendo 70 doentes sofrido pelo menos um episódio de VPO (3,3%). Foram consideradas variáveis a analisar, a idade, o sexo, a especialidade cirúrgica, o estado físico (ASA), a técnica anestésica e a duração da anestesia. Procedeu-se à análise estatística de cada factor individualmente através da aplicação do χ2, seguindo-se a utilização de uma regressão logística para identificar a força de associação multivariável desses factores. O sexo feminino (Odds ratio =4,94) e a duração da anestesia quando superior a 180 minutos (OR =8,13), associaram-se a uma maior incidência de VPO enquanto a técnica loco-regional (OR =0,15) e a sedação com anestesia local (OR =0,09) se associaram a uma menor incidência daqueles. Os autores evidenciam a importância deste tipo de trabalhos na identificação de factores de risco que possam levar à criação de escalas de risco que orientem com maior racionalidade económica, a intervenção terapêutica profiláctica das náuseas e vómitos no pós-operatório.
- Multicentric Genome-Wide Association Study for Primary Spontaneous PneumothoraxPublication . Sousa, I.; Abrantes, P.; Francisco, V.; Teixeira, G.; Monteiro, M.; Neves, J.; Norte, A.; Robalo-Cordeiro, C.; Moura-Sá, J.; Reis, E.; Santos, P.; Oliveira, M.; Sousa, S.; Fradinho, M.; Malheiro, F.; Negrão, L.; Feijó, S.; Oliveira, S.Despite elevated incidence and recurrence rates for Primary Spontaneous Pneumothorax (PSP), little is known about its etiology, and the genetics of idiopathic PSP remains unexplored. To identify genetic variants contributing to sporadic PSP risk, we conducted the first PSP genome-wide association study. Two replicate pools of 92 Portuguese PSP cases and of 129 age- and sex-matched controls were allelotyped in triplicate on the Affymetrix Human SNP Array 6.0 arrays. Markers passing quality control were ranked by relative allele score difference between cases and controls (|RASdiff|), by a novel cluster method and by a combined Z-test. 101 single nucleotide polymorphisms (SNPs) were selected using these three approaches for technical validation by individual genotyping in the discovery dataset. 87 out of 94 successfully tested SNPs were nominally associated in the discovery dataset. Replication of the 87 technically validated SNPs was then carried out in an independent replication dataset of 100 Portuguese cases and 425 controls. The intergenic rs4733649 SNP in chromosome 8 (between LINC00824 and LINC00977) was associated with PSP in the discovery (P = 4.07E-03, ORC[95% CI] = 1.88[1.22-2.89]), replication (P = 1.50E-02, ORC[95% CI] = 1.50[1.08-2.09]) and combined datasets (P = 8.61E-05, ORC[95% CI] = 1.65[1.29-2.13]). This study identified for the first time one genetic risk factor for sporadic PSP, but future studies are warranted to further confirm this finding in other populations and uncover its functional role in PSP pathogenesis.
- Oral soft tissue biopsies in Oporto, Portugal: An eight year retrospective analysisPublication . Guedes, M.; Albuquerque, R.; Monteiro, M.; Lopes, C.; Barbas- Amaral, J.; Pacheco, J.; Monteiro, L.The diseases that affect the oral cavity are wide and diverse, comprising a broad spectrum of either benign or malignant lesions. However, few histological-based studies were performed for the evaluation of oral cavity lesions, and very few directed to oral soft tissue pathology. The aim of this study was to carry out pioneering research, within a Portuguese population, to determine the frequency and characteristics of oral malignancies, potential malignant disorders, and soft benign tissues pathologies submitted for biopsy in a north Portugal (Oporto) hospital population.
- Visceral Obesity and Metabolic Syndrome Are Associated with Well-Differentiated Gastroenteropancreatic Neuroendocrine TumorsPublication . Santos, A.; Santos, A.; Castro, C.; Raposo, L.; Pereira, S.; Torres, I.; Henrique, R.; Cardoso, H.; Monteiro, M.The determinants for gastroenteropancreatic neuroendocrine tumors (GEP-NET) recent burden are matters of debate. Obesity and metabolic syndrome (MetS) are well established risks for several cancers even though no link with GEP-NETs was yet established. Our aim in this study was to investigate whether well-differentiated GEP-NETs were associated with obesity and MetS. Patients with well-differentiated GEP-NETs (n = 96) were cross-matched for age, gender, and district of residence with a control group (n = 96) derived from the general population in a case-control study. Patients presented gastro-intestinal (75.0%) or pancreatic (22.9%) tumors, grade G1 (66.7%) or G2 (27.1%) with localized disease (31.3%), regional metastasis (16.7%) or distant metastasis (43.8%) at diagnosis, and 45.8% had clinical hormonal syndromes. MetS was defined according to Joint Interim Statement (JIS) criteria. Well-differentiated GEP-NETs were associated with MetS criteria as well as the individual components' waist circumference, fasting triglycerides, and fasting plasma glucose (p = 0.003, p = 0.002, p = 0.011 and p < 0.001, respectively). The likelihood of the association was higher when the number of individual MetS components was greater than four. MetS and some individual MetS components including visceral obesity, dyslipidemia, and increased fasting glucose are associated with well-differentiated GEP-NET. This data provides a novel insight in unraveling the mechanisms leading to GEP-NET disease.