Browsing by Author "Moreira, I."
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- Assimetria motora inicial e sintomas não motores na Doença de ParkinsonPublication . Gonçalves, A.; Mendes, A.; Vila-Chã, N.; Moreira, I.; Lima, A.; Cavaco, S.
- A DRS-2 na Doença de HuntingtonPublication . Fernandes, J.; Moreira, I.; Damásio, J.; Loureiro, R.; Magalhães, M.; Cavaco, S.
- Long-term psychological outcome after discharge from intensive carePublication . Pereira, S.; Cavaco, S.; Fernandes, J.; Moreira, I.; Almeida, E.; Seabra-Pereira, F.; Castro, H.; Malheiro, M.; Cardoso, A.; Aragão, I.; Cardoso, T.Objective: To investigate the longterm psychological outcome in survivors of critical illness after intensive care unit discharge. Methods: A prospective cohort of survivors admitted to a mixed intensive care unit between January and September 2010 was evaluated six months and five years after hospital discharge. The Dementia Rating Scale-2, the Hospital Anxiety and Depression Scale, the Posttraumatic stress syndrome 14-questions inventory, the Euro Quality of Life 5 Dimensions (EQ-5-D), and the Visual Analogue Scale (EQ VAS) were assessed at both follow-up periods. Results: Of 267 patients, 25 patients were evaluated at 6 months after discharge (62 ± 16 years); 12 (48%) presented cognitive impairment, 6 (24%) anxiety, 4 (16%) depression, and 4 (16%) post-traumatic stress disorder. Among those re-evaluated five years after discharge (n = 17; 65 ± 15 years), the frequency of cognitive impairment dropped from 8 (47%) to 3 (18%) (p = 0.063), due to improvement in these patients over time, and other patients did not acquire any dysfunction after discharge. At five years after discharge, only two patients (12%) reported anxiety, and none had depression or post-traumatic stress disorder. No differences were found between the six-month and five-year follow-ups regarding EQ-5-D and EQ VAS. Conclusion: Survivors do not show a progressive decline in cognitive function or quality of life within five years after intensive care unit discharge. Psychopathological symptoms tend to decrease with time.
- Neurological involvement in Primary Sjögren’s SyndromePublication . Teixeira, F.; Moreira, I.; Martins-Silva, A.; Vasconcelos, C.; Farinha, F.; Santos, E.
- Sleep disturbances in Parkinson's disease are associated with central parkinsonian painPublication . Vila-Chã, N.; Cavaco, Sara; Mendes, A.; Gonçalves, A.; Moreira, I.; Fernandes, J.; Damásio, Joana; Azevedo, Luís; Castro-Lopes, JoseIntroduction: Sleep disturbances and pain are common non-motor symptoms in Parkinson's disease (PD). This study aimed to explore the association between these two symptoms in a cohort of patients with PD. Materials and methods: The Parkinson's Disease Sleep Scale (PDSS-2) was used to identify sleep disturbances in a series of 229 PD patients. The identification and characterization of pain was performed by a semi-structured interview and by the application of the Ford classification and the Brief Pain Inventory (BPI). The Unified Parkinson's Disease Rating Scale-III, Hoehn & Yahr (H&Y), and Schwab and England Independence Scale were used to assess motor symptoms and functional independence in off and on conditions. The Hospital Anxiety and Depression Scale (HADS) and SF-36 were applied to screen for anxiety and depression and to evaluate the quality of life. Non-parametric tests were used for group comparisons and logistic regressions were applied to explore predictors of sleep disturbances. Results: Seventy-five (33%) patients had clinically relevant sleep disturbances (PDSS-2≥18) and 162 patients (71%) reported pain. Of those with pain, 38 (24%) had central parkinsonian pain. PD patients with sleep disturbances experienced more pain and had more severe motor symptoms, lower functional independence, more anxiety and depression symptoms, and worst quality of life. Among patients with pain, central parkinsonian pain was the subtype of pain with the highest odds of sleep disturbances, even when taking into account motor symptoms (H&Y off), motor fluctuations, intensity of pain (BPI), and symptoms of anxiety and depression (HADS). Conclusions: The association between pain and sleep disturbances in PD appears to be dependent on subtype of pain. The close relationship between central parkinsonian pain and sleep disturbances in PD raises the possibility of common pathophysiological mechanisms. A better understanding of the relationship between sleep disturbances and central parkinsonian pain may contribute to the development of new care strategies in PD patients.
- Stent Thrombosis Eight Years Past Drug-Eluting Stent Placement – A Case ReportPublication . Baptista, A.; Ferreira, C.; Mateus, P.; Cyrne-Carvalho, H.; Moreira, I.
- The spectrum of mutations and molecular pathogenesis of hemophilia A in 181 Portuguese patientsPublication . David, D.; Ventura, C.; Moreira, I.; Diniz, M.; Antunes, M.; Tavares, A.; Araújo, F.; Morais, S.; Campos, M.; Lavinha, J.; Kemball-Cook, G.Disease-causing alterations within the F8 gene were identified in 177 hemophilia A families of Portuguese origin. The spectrum of non-inversion F8 mutations in 101 families included 67 different alterations, namely: 36 missense, 8 nonsense and 4 splice site mutations, as well as 19 insertions/deletions. Thirty-four of these mutations are novel. Molecular modeling allowed prediction of the conformational changes introduced by selected amino acid substitutions and their correlation with the patients' phenotypes. The relatively frequent, population-specific, missense mutations together with de novo alterations can lead to significant differences in the spectrum of F8 mutations among different populations