Browsing by Author "Saraiva, S."
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- Health-related quality of life and utilities in gastric premalignant conditions and malignant lesions: a multicentre study in a high prevalence countryPublication . Areia, M.; Alves, S.; Brito, D.; Cadime, A.; Carvalho, R.; Saraiva, S.; Ferreira, S.; Moleiro, J.; Pereira, A.; Carrasquinho, J.; Lopes, L.; Ramada, J.; Marcos-Pinto, R.; Pedroto, I.; Contente, L.; Eliseu, L.; Vieira, A.; Sampaio, M.; Sousa, H.; Almeida, N.; Gregório, C.; Portela, F.; Sofia, C.; Braga, V.; Baginha, E.; Bana e Costa, T.; Chagas, C.; Mendes, L.; Magalhães-Costa, P.; Matos, L.; Gonçalves, F.; Dinis-Ribeiro, M.BACKGROUND AND AIMS: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument. METHODS: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire. RESULTS: According to EQ-5D-5L, utilities in individuals without gastric lesions were 0.78 (95% confidence interval: 0.76-0.80), with gastric premalignant conditions 0.79 (0.77-0.81), previously treated for gastric cancer 0.77 (0.73-0.81) and with present cancer 0.68 (0.55-0.81). Self-reported QoL according to the visual analogue scale (VAS) for the same groups were 0.67 (0.66-0.69), 0.67 (0.66-0.69), 0.62 (0.59-0.65) and 0.62 (0.54-0.70) respectively. Utilities were consistently lower in women versus men (no lesions 0.71 vs. 0.78; premalignant conditions 0.70 vs. 0.82; treated for cancer 0.72 vs. 0.78 and present cancer 0.66 vs. 0.70). CONCLUSION: The health-related QoL utilities of patients with premalignant conditions are similar to those without gastric diseases whereas patients with present cancer show decreased utilities. Moreover, women had consistently lower utilities than men. These results confirm that the use of a single standardized instrument such as the EQ-5D-5L for all stages of the gastric carcinogenesis cascade is feasible and that it captures differences between conditions and gender dissimilarities, being relevant information for authors pretending to conduct further cost-utility analysis.
- Infecção por citomegalovirus. Uma forma rara de apresentaçãoPublication . Sotto Maior, T.; Aguiar, A.; Saraiva, S.; Santos, P.; Gonçalves, C.; Aroso, S.RESUMO A infecção por Citomegalovirus (CMV) é uma situação frequente, ocorrendo maioritariamente de forma assintomática(1). Os autores apresentam o caso clínico de uma criança de 3 anos de idade, internada no Serviço de Pediatria do Hospital Pedro Hispano para estudo etiológico de hipoproteinémia com hipoalbuminémia, no contexto clínico de vómitos, abdominalgias e edemas infraorbitários bilaterais. Os exames complementares de diagnóstico efectuados inicialmente permitiram excluir etiologia hepática e renal. Perante a suspeita de uma enteropatia perdedora de proteínas foi efectuada uma endoscopia digestiva alta que revelou ulcerações superficiais da mucosa gástrica. A pesquisa do CMV por técnica de PCR (Protein Chain Reaction) em tecido de biopsia gástrica e duodenal foi positiva. As serologias para CMV foram sugestivas de infecção recente. A evolução clínica e analítica foi favorável, tendo sido apenas instituído tratamento sintomático.