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Publication
Alergia a fármacos na criança
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Advisor(s)
Abstract(s)
RESUMO
As reacções alérgicas a fármacos
fazem parte do universo mais alargado
das reacções adversas a fármacos e a
sua classificação implica a demonstração
de um mecanismo imunológico especifico
subjacente. Estas reacções são frequentes
quer em adultos quer em idades
pediátricas e acarretam morbilidade e
mesmo mortalidade apreciável. A sua
investigação, a ser realizada em meio
hospitalar, assenta numa anamenese
cuidadosa complementada por testes in
vivo e ocasionalmente por testes in vitro.
Só o estabelecimento de um diagnóstico
correcto permite o aconselhamento do
doente relativamente a futuras opções
terapêuticas, evitando riscos de novas
reacções e o uso indiscriminado de fármacos
menos eficazes e mais dispendiosos.
Esta investigação é também
fundamental para o progresso na compreensão
dos mecanismos fisiopatológicos
envolvidos o que permitirá implementar
melhores medidas preventivas.
ABSTRACT Allergic reactions to drugs are part of the wider universe of adverse drug reactions and its classification depends on the demonstration of an underlying specific immunological mechanism. These reactions are quite frequent among adults and children and cause significant morbillity and even mortality. The diagnostic work-up to be made at the hospital is based on a detailed clinical history and on in vivo investigation procedures as the laboratory has a minor contribution. The establishment of a diagnosis provides the patient with information about future therapeutical options, reduces the risk of new reactions and prevents the misuse of alternative drugs. Besides, the full investigation allows the progression in the understanding of the involved mechanisms, which can contribute to the implementation of better protection measures.
ABSTRACT Allergic reactions to drugs are part of the wider universe of adverse drug reactions and its classification depends on the demonstration of an underlying specific immunological mechanism. These reactions are quite frequent among adults and children and cause significant morbillity and even mortality. The diagnostic work-up to be made at the hospital is based on a detailed clinical history and on in vivo investigation procedures as the laboratory has a minor contribution. The establishment of a diagnosis provides the patient with information about future therapeutical options, reduces the risk of new reactions and prevents the misuse of alternative drugs. Besides, the full investigation allows the progression in the understanding of the involved mechanisms, which can contribute to the implementation of better protection measures.
Description
Keywords
Alergia a fármacos Hipersensibilidade a fármacos Investigação clínica criança Drug Allergy drug hypersensitivity diagnostic work-up children
Citation
Nascer e Crescer 2005; 14 (2): 96-101
Publisher
Revista Nascer & Crescer