Browsing by Author "Monteiro, L."
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- A clinical-pathological and survival study of oral squamous cell carcinomas from a population of the North of PortugalPublication . Monteiro, L.; Barbas-Amaral, J.; Vizcaíno, J.; Lopes, C.; Torres, F.OBJECTIVES: Our aim was to analyze the clinical, pathological, and outcome characteristics of oral squamous cell carcinomas (OSCC) from a population of the North of Portugal. MATERIAL AND METHODS: We conducted a descriptive study of 128 OSCC diagnosed between the years of 2000 and 2010 in the Centro Hospitalar do Porto. Through of the review of the clinical records we studied several clinical, pathological, and outcome variables. The overall survival (OS) and disease-free survival (DFS) were analyzed by Kaplan-Meier method and log-rank test. Cox regression method was used for multivariate analysis. RESULTS: Of 128 patients with OSCC, 83 (64.8%) were male and 45 (35.2%) were female, (mean age of 62.13±15.57 years). The most affected location was the tongue (n=52; 40.6%). The most common cause of reference was a non-healing ulcer (n=35; 28.9%) followed by oral pain (n=27; 22.3%). Sixty (60.6%) patients were tobacco consumers and 55 (57.3%) alcohol consumers. The cumulative 3-years OS rate was 58.6% and DFS was 55.4%. In multivariable analysis for OS, we found an adverse independent prognostic value for advanced tumour size (p<0.001) and for the presence of perineural permeation (p=0.012). For DFS, advanced stage tumours presented adverse independent prognostic value (p<0.001). CONCLUSION: OSCC occurred most frequently in males, in older patients, and in patients with tobacco and/or alcohol habits. TNM and tumour stage additionally to the perineural permeation were the most important prognostic factor for the survival of these patients, contributing to identify high-risk subgroups and to guide therapy.
- EMMPRIN expression in oral squamous cell carcinomas: correlation with tumor proliferation and patient survivalPublication . Monteiro, L.; Delgado, M.; Ricardo, S.; Garcez, F.; Barbas-Amaral, J.; Pacheco, J.; Lopes, C.; Bousbaa, H.The aim of our study was to explore the clinicopathological and prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) expression in oral squamous cell carcinomas (OSCC), and its relation with the proliferative tumor status of OSCC. We examined EMMPRIN and Ki-67 proteins expression by immunohistochemistry in 74 cases with OSCC. Statistical analysis was conducted to examine their clinicopathological and prognostic significance in OSCC. EMMPRIN membrane expression was observed in all cases, with both membrane and cytoplasmic tumor expression in 61 cases (82.4%). EMMPRIN overexpression was observed in 56 cases (75.7%). Moderately or poorly differentiated tumors showed EMMPRIN overexpression more frequently than well-differentiated tumors (P = 0.002). Overexpression of EMMPRIN was correlated with high Ki-67 expression (P = 0.004). In the multivariate analysis, EMMPRIN overexpression reveals an adverse independent prognostic value for cancer-specific survival (CSS) (P = 0.034). Our results reveal that EMMPRIN protein is overexpressed in more than two-thirds of OSCC cases, especially in high proliferative and less differentiated tumors. The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC. Moreover, the high expression of EMMPRIN makes it a possible therapeutic target in OSCC patients.
- Grisi - Grupo de Rastreio e Intervenção da Surdez InfantilPublication . Coutinho, M.; Monteiro, L.
- Oral soft tissue biopsies in Oporto, Portugal: An eight year retrospective analysisPublication . Guedes, M.; Albuquerque, R.; Monteiro, M.; Lopes, C.; Barbas- Amaral, J.; Pacheco, J.; Monteiro, L.The diseases that affect the oral cavity are wide and diverse, comprising a broad spectrum of either benign or malignant lesions. However, few histological-based studies were performed for the evaluation of oral cavity lesions, and very few directed to oral soft tissue pathology. The aim of this study was to carry out pioneering research, within a Portuguese population, to determine the frequency and characteristics of oral malignancies, potential malignant disorders, and soft benign tissues pathologies submitted for biopsy in a north Portugal (Oporto) hospital population.
- Rastreio da Audição em Idade PediátricaPublication . Monteiro, L.RESUMO A deficiência auditiva infantil tem uma incidência superior a todas as doenças congénitas para as quais já existe rastreio sistemático e condiciona o normal desenvolvimento das capacidades linguísticas. O rasteio universal dos recém-nascidos e a intervenção precoce (antes dos seis meses de idade) são actualmente recomendados como boa prática clínica. Ao longo da infância pode surgir deficiência auditiva de variados graus provocada por doenças, traumatismos, ou por expressão tardia de hipoacúsia de causa genética. Há por isso necessidade de reconhecer estas situações, estabelecendo programas de rastreios adequados. O rastreio em idade pré-escolar visa detectar os casos de hipoacúsia que possam interferir com o desempenho escolar e não tenham sido previamente diagnosticadas. ABSTRACT Pediatric hearing loss is the most frequent congenital disease detectable by systematic screening and may interfere with normal acquisition of linguistic skills. Universal newborn hearing screening and early intervention (before six months of age) is considered a good clinical practice, according to present standards. During childhood, new cases of hearing loss of different degrees of severity can occur: after some diseases, trauma, or as late manifestation of genetic hearing loss. Professionals should recognize this situations and appropriate screening programs should be designed. The goal of pre-school screening programs is the detection of undiagnosed cases of hearing loss, which may difficult normal academic performance.