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- Extensive colectomy in colorectal cancer and hereditary nonpolyposis colorectal cancer – long-term resultsPublication . Santos, Marisa D.; Silva, C.; Oliveira, J.; Brandão, P.; Sampaio, M.; Silva, A.; Rocha, A.; Matos, E.; Marcos-Pinto, R.Background: Colorectal cancer survival is better in hereditary nonpolyposis colorectal cancer patients than in sporadic colorectal cancer patients and even for hereditary nonpolyposis colorectal cancer with colorectal cancer is not consensual that extensive colectomy is preferable to partial colectomy. This study analyzes and compares the long-term results of these two groups of patients submitted to curative subtotal colectomy or total colectomy. Methods: Between 2002 and 2018, 68 patients with colorectal cancer without familial adenomatous polyposis were submitted to a total or subtotal colectomy in a single tertiary center. The patients were divided in two groups: hereditary nonpolyposis colorectal cancer patients (with Amsterdam criteria) and sporadic colorectal cancer patients (the others). The presence of Amsterdam criteria for hereditary nonpolyposis colorectal cancer and germline mutation for mismatch repair genes was confirmed by clinical records. Results and survival were analyzed following surgery. Results: We obtained a sporadic colorectal cancer group with 31 patients and a hereditary nonpolyposis colorectal cancer group with 37 patients. The two groups differ in age but not in gender, tumor stage or surgical morbidity. The overall survival and disease-free survival were good in both groups but even better for hereditary nonpolyposis colorectal cancer group with statistical significance when comparing the two groups. Conclusion: Total or subtotal colectomy for colorectal cancer provides a good survival. These surgical procedures should be considered the first option for colorectal cancer in young hereditary non polyposis colorectal cancer patients. In those cases, they provide good long-term results, avoiding the risk of metachronous colorectal cancer and the surveillance is restricted only to the remaining need for rectum.
- Diabetes Gestacional como Fator de Risco CardiovascularPublication . Dores, J.
- Caso Endoscópico: Obstrução esofágica por corpo estranhoPublication . Pereira, F.
- Caso endoscópico: esofagite gravePublication . Pereira, F.ABSTRACT We present the case of a eight-year old boy with microcytic hypochromic anemia, who refused to ingest meat products for the last years. He had a good response to therapy with oral iron supplements, but with further recurrence of symptoms after stopping treatment. Investigation by Haematology was inconclusive. The upper endoscopy showed severe peptic esophagitis with stenosis. The patient was treated with proton pump inhibitors, dilation of the stenosis and surgery (Nissen fundoplication), with good outcome.
- Caso endoscópico: Esofagite eosinofílicaPublication . Pereira, F.A six year-old boy presented with chronic nocturnal cough. History of bronchial asthma controlled with medical treatment, alergy to house dust and acarus. Upper endoscopy and biopsy confirmed criteria for eosinophilic esophagitis. There was a good response to swallowed fluticasone.
- Caso Endoscópico: Manifestação esofágica da Disqueratose CongénitaPublication . Pereira, F.
- Caso endoscópico: Doença de CrohnPublication . Pereira, F.ABSTRACT A case of a fourteen years old boy with complaints of dispepsia in the last 2 months associated with anorexia end weight loss is presented. He had frequent bowel movements (4-5 times a day), some during the night, for the last one and a half year. He presented hypocromic microcytic anemia with low serum iron and ferritin, and elevated values of ESR and PCR. The upper digestive endoscopy showed ulcerative esophagitis with inflammatory infiltrate of the mucosa, with the participation of lymphocytes, plasmocytes and neutrophils but without eosinophils. Colonoscopy and colon biopsies confirmed the diagnosis of Crohn colitis. Diagnosis: Crohn disease with esophageal lesions.
- Doente Neurologicamente Comprometido Gastrostomia e EnterostomiaPublication . Pereira, F.
- Caso Endoscópico; Polipose cólica JuvenilPublication . Pereira, F.